Descriptive epidemiology of varicella based on national surveillance data before and after the introduction of routine varicella vaccination with two doses in Japan, 2000-2017

Vaccine
Saeko MorinoKazunori Oishi

Abstract

Routine childhood immunization using two doses of the varicella vaccine was introduced in Japan in October 2014. In this study, we analyzed the data extracted from national varicella surveillance, including pediatric sentinel surveillance from 2000 to 2017 and hospitalized varicella surveillance from the 38th week of 2014 to the 37th week of 2017. Compared with the 2000-2011 baseline data, the number of varicella cases per sentinel decreased substantially by 76.6% overall and by 88.2% among children aged 1-4 years in 2017. Of 997 hospitalized patients, we found a decreasing trend in the number of cases among children aged <5 years. We also found a decreasing trend in the number of cases with complications among children aged 1-4 years. Data on the self-reported transmission sites in 35.5% (354/997) of the hospitalized varicella patients showed that transmission of varicella zoster virus (VZV) occurred frequently in household, at school for young children, in the workplace for adults, and at hospital for all age groups. Data from 29.0% (289/997) of the hospitalized patients with a self-reported source of infection showed that transmission of VZV occurred from a patient with herpes zoster (HZ) in 30.4% (88/289) of cases. Our data...Continue Reading

Citations

Jun 19, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshihiko MorikawaYuho Horikoshi
Apr 25, 2020·The Science of the Total Environment·Jian-Yun LuZhi-Cong Yang
Jul 22, 2021·Hospital Pediatrics·José Fontoura-MatiasInês Azevedo
Oct 7, 2021·Human Vaccines & Immunotherapeutics·Yasutaka KuniyoshiMakoto Tashiro
Mar 30, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Takayuki HoshinaKoichi Kusuhara
Dec 12, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Sayaka Takanashi, Keiko Tanaka-Taya

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