Descriptive study of 32 cases of doxycycline-overdosed calves

Journal of Veterinary Internal Medicine
M BrihoumF Rollin

Abstract

Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves. To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously. Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders. Retrospective review of medical records. Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver. Mos...Continue Reading

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Citations

Jul 27, 2011·BMC Veterinary Research·Mounir BrihoumHélène Amory
Feb 26, 2013·International Journal of Experimental Pathology·Mahmoud Shaban El-Neweshy
Jun 12, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tingting ZhangDen Guo
Jul 31, 2019·Drug Development Research·Ying HuangChuanbin Wu
Feb 28, 2020·Journal of Applied Physiology·C Brooks MobleyJohn J McCarthy
Jun 5, 2020·Oral Diseases·Yi ShuaiLei Jin
Aug 27, 2019·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Vassilis D LitskasDimitris S Koveos

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