Desensitization and capsaicin-induced release of substance P-like immunoreactivity from guinea-pig ureter in vitro.

Neuroscience
A DrayJ C Yeats

Abstract

Substance P-like immunoreactivity was assayed in superfusates of guinea-pig ureters following stimulation of afferent fibres with capsaicin, potassium chloride and the calcium channel agonist Bay K 8644. Capsaicin-evoked release of substance P-like immunoreactivity was calcium-dependent but unaffected by cobalt. Under appropriate conditions release was dose-related (ED50 = 610 nM) and reproducible. Selective desensitization to capsaicin could be demonstrated following prolonged exposure to different doses of capsaicin. No desensitization to capsaicin was observed following afferent fibre stimulation with a combination of Bay K 8644 and K+, which released a similar amount of substance P-like immunoreactivity as a desensitizing capsaicin stimulus. These data suggest that depletion of releasable substance P-like reactivity is unlikely to account for selective desensitization of ureteric primary afferent fibres to capsaicin.

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Citations

Oct 9, 1990·European Journal of Pharmacology·A DickensonA Dray
Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
Jan 1, 1991·Life Sciences·R Amann, C A Maggi
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
Jan 1, 1991·Annals of the New York Academy of Sciences·R Amann, F Lembeck
Aug 18, 1992·Biochemical Pharmacology·A Dray
Feb 1, 1991·Brain Research·E KirályM Hajós
Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·R Amann

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