PMID: 5723May 1, 1976

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides

Proceedings of the National Academy of Sciences of the United States of America
C Mukherjee, R J Lefkowitz

Abstract

Incubation of purified frog erythrocyte membranes with beta-adrenergic agonists at 25 degrees produces relatively rapid (half-time about 10 min) desensitization (inactivation) of about 60% of the beta-adrenergic receptor binding sites. The desensitized receptors no longer bind the specific beta-adrenergic ligand (-)[3H]dihydroalprenolol. The decrease in the number of functional beta-adrenergic receptors is also manifest as a decreased ability of isoproterenol to stimulate the membrane-bound adenylate cyclase.

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Related Concepts

Adenylate Cyclase
Adrenergic beta-Agonists
Alprenolol Hydrochloride
Plasma Membrane
Cell-Free System
Dose-Response Relationship, Drug
Enzyme Activation
Erythrocytes
Guanosine Triphosphate
Novodrin

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