PMID: 6160070Nov 1, 1980Paper

Desensitization of cultured rat Sertoli cells by follicle-stimulating hormone and by L-isoproterenol

Molecular and Cellular Endocrinology
G VerhoevenP de Moor

Abstract

When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accumulates in the medium and in the cells. The extent of desensitization depends on the concentration of FSH or L-isoproterenol to which the cells have been exposed and on the duration of this previous contact. Pre-incubation with FSH results in cross-desensitization for L-isoproterenol. Comparable heterologous desensitization is not observed after pre-incubation with L-isoproterenol. This suggests that down-regulation of the respective receptors cannot be the only explanation. Refractoriness can also be induced by dbcAMP. This opens the possibility that cAMP itself contributes to the homologous and heterologous desensitization process.

References

Jul 1, 1975·Molecular and Cellular Endocrinology·J H DorringtonI B Fritz
Aug 29, 1978·Biochemical and Biophysical Research Communications·J L Hartley, R L Soffer
Aug 29, 1978·Biochemical and Biophysical Research Communications·A M MoreraJ M Saez
Mar 1, 1979·Molecular and Cellular Endocrinology·T J Weiss, D T Armstrong
Oct 18, 1976·Biochemical and Biophysical Research Communications·C RoyS Jard

❮ Previous
Next ❯

Citations

Oct 1, 1981·Molecular and Cellular Endocrinology·G VerhoevenP de Moor
Jan 1, 1983·Molecular and Cellular Endocrinology·M ContiM Stefanini
Oct 1, 1984·Molecular and Cellular Endocrinology·C Hertel, J P Perkins
Jan 1, 1984·Molecular and Cellular Endocrinology·H AttramadalV Hansson
Aug 1, 1985·Molecular and Cellular Endocrinology·R B OonkH J van der Molen
Jan 2, 1990·Molecular and Cellular Endocrinology·I A KlaijJ A Grootegoed
Dec 12, 2001·Reproductive Toxicology·N M BiswasM Sarkar
Jun 30, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·William H Walker, Jing Cheng
Jan 1, 1982·Annals of the New York Academy of Sciences·J P MatherD M Phillips
Mar 30, 1982·Biochemical and Biophysical Research Communications·K D BrownB P Setchell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.