PMID: 15374226Jul 1, 1995Paper

Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?

Archives of Gerontology and Geriatrics
N Henneberg, S Hoyer

Abstract

Even in its incipient stage, late-onset sporadic dementia of the Alzheimer type (SDAT) is characterized by an abnormal reduction in brain glucose consumption and energy formation. Gathering evidence indicates that cerebral glucose metabolism is controlled by brain insulin/insulin receptors. This led us to hypothesize that the abnormal reduction in glucose utilization found in Alzheimer brains is preceded by a desensitization of cerebral insulin receptors which might be due to enhanced levels of stress factors such as cortisol and catecholamines. The hypothesis is supported by clinical findings of an abnormal response to the oral glucose tolerance test in AD patients. Furthermore, experimental desensitization of the cerebral insulin receptor resulted in both cognitive deficits and metabolic abnormalities in cerebral oxidative glucose metabolism resembling those described in incipient late-onset SDAT. Glucose is the major source of energy in the CNS, and any impairment in cerebral glucose oxidation can be expected to result in deficits in both acetylcholine synthesis and ATP formation, which might contribute to altered APP processing and enhanced susceptibility to neurotoxicity.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J HavrankovaM Brownstein
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D BuxbaumP Greengard
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M MossJ N Livingston
Oct 1, 1991·Trends in Pharmacological Sciences·J Hardy, D Allsop
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Jul 1, 1990·Neuroendocrinology·H C HornerR M Sapolsky
Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·R A SwansonF R Sharp
Sep 13, 1990·Nature·P H St George-HyslopUNKNOWN FAD Collaborative Study Group
Sep 1, 1989·The Journal of Clinical Investigation·J MeyerovitchC R Kahn
Mar 1, 1987·Journal of Neurochemistry·R B Duckrow, R M Bryan
Jan 1, 1986·The Journal of Clinical Investigation·C F BurantM G Buse
Jan 1, 1987·The International Journal of Biochemistry·M T RinaudoM Mostert
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M KyriakisS W Peterson
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen

❮ Previous
Next ❯

Citations

Mar 30, 2006·Diabetologia·A M HennigeH-U Häring
Dec 18, 2013·Journal of Neural Transmission·A Popa-WagnerD Muresanu
Mar 10, 2005·Neurobiology of Disease·Paula I MoreiraCatarina R Oliveira
Jan 26, 2011·Ageing Research Reviews·Sónia C CorreiaMark A Smith
Mar 5, 2016·Acta Neurologica Scandinavica·M-H LoC-H Kao
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Konrad Talbot, Hoau-Yan Wang
Oct 4, 2014·Pharmacotherapy·Grzegorz M Rdzak, Osama Abdelghany
Aug 28, 2012·Physiology & Behavior·Taisa Oliveira SantosAndréa Silva Torrão
Mar 6, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Andréa S TorrãoLuiz R G Britto
Jan 30, 2008·Journal of Chemical Neuroanatomy·Hans-Gert BernsteinBernhard Bogerts
Nov 5, 1997·Annals of the New York Academy of Sciences·W A Meier-Ruge, C Bertoni-Freddari
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Niloofar BazazzadeganHamid Reza Khorram Khorshid
Dec 5, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Oriol BusquetsAntoni Camins
Jan 8, 2020·International Journal of Molecular Sciences·Oriol BusquetsAntoni Camins
Aug 29, 2018·Journal of Alzheimer's Disease : JAD·Fernanda CrunfliAndréa da Silva Torrão
Apr 20, 2004·European Journal of Pharmacology·K Gerozissis
Apr 20, 2004·European Journal of Pharmacology·Siegfried Hoyer
Jun 20, 2021·Metabolic Brain Disease·Paulina Belén Sepulveda FigueroaAndréa da Silva Torrão
Feb 24, 2007·Journal of the Neurological Sciences·Paula I MoreiraCatarina R Oliveira

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.