PMID: 7539127Jan 1, 1995Paper

Desensitization of the response to thyrotropin-releasing hormone in Xenopus oocytes is an amplified process that precedes calcium mobilization

Pflügers Archiv : European journal of physiology
D LipinskyY Oron

Abstract

Consecutive challenges with thyrotropin-releasing hormone (TRH) of oocytes expressing the TRH receptor (TRH-R) resulted in a pronounced desensitization, manifested as a decrease in chloride current amplitude and an increase in response latency. Exposure to low concentrations of TRH resulted in a marked decrease in the amplitude of the subsequent response to a higher concentration of the agonist, even though the second challenge was given before the onset of the response to the first challenge (within 3 - 15 s). Cellular calcium concentration ([Ca]i) did not increase within this interval, suggesting that calcium was not involved in the desensitization process. The latency of the second response, however, was either unchanged or shortened, implying additive effects of processes initiated by the first challenge. A longer interval (30 s) between the two challenges brought about a more pronounced decrease in amplitude and a prolongation of response latency. The calcium mobilization initiated by a second challenge with a high concentration of the agonist exhibited a longer latency, a lower rate of [Ca]i increase and a lower amplitude. Stimulation of co-expressed cholinergic-muscarinic ml receptors with a low concentration of acetylch...Continue Reading

References

Apr 1, 1992·Journal of Basic and Clinical Physiology and Pharmacology·H ShapiraY Oron
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N S RothM J Lohse
Oct 1, 1991·Trends in Biochemical Sciences·K Palczewski, J L Benovic
Dec 1, 1990·Pflügers Archiv : European journal of physiology·M Lupu-MeiriY Oron
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R E StraubM C Gershengorn
Nov 15, 1990·Biochemical and Biophysical Research Communications·J M HerbertJ P Maffrand
Mar 1, 1989·Pflügers Archiv : European journal of physiology·M Lupu-MeiriY Oron
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R B ClarkJ A Johnson
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y OronM C Gershengorn
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J L BenovicR J Lefkowitz
Nov 7, 1993·Biochimica Et Biophysica Acta·M J Lohse

❮ Previous
Next ❯

Citations

Mar 31, 2005·Journal of Cellular Physiology·Irit Itzhaki Van-Ham, Yoram Oron
Mar 24, 1999·Neuroscience and Behavioral Physiology·G A BuznikovJ M Lauder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.