Desensitization of type 1 angiotensin II receptor subtypes in the rat kidney

Endocrinology
Annette Hus-CitharelC Llorens-Cortes

Abstract

Differences involving serine residues in the sequence of the carboxyl-terminal tail of type 1 angiotensin II (Ang II) receptor subtypes AT(1A) and AT(1B) suggest differences in desensitization ability. We examined the Ang II-induced homologous desensitization patterns of both receptor subtypes in freshly isolated renal structures: glomerulus (Glom), afferent arteriole, and cortical thick ascending limb (CTAL), whose content in each subtype mRNA is different, by measuring variations in intracellular calcium concentration. A preexposure to a maximal dose of Ang II, followed by a second application of the same concentration, induced: 1) a complete desensitization in Glom, where AT(1A) and AT(1B) mRNAs were expressed in similar proportions, and 2) no or partial desensitization in afferent arteriole and CTAL, where AT(1A) mRNA was predominant. In the absence of nephron structure containing only AT(1B) mRNA, we studied rat anterior pituitary cells that exhibit high content in this subtype and observed that desensitization was not complete. In Glom, CTAL, and pituitary cells, desensitization proceeded in a dose-dependent manner. In Glom and CTAL, desensitization occurred via a PKC-independent mechanism. These results suggest that dese...Continue Reading

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Citations

Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ImanishiKimio Tomita
Sep 24, 2004·Physiological Reviews·Carsten A WagnerJohn P Geibel
Nov 2, 2006·American Journal of Physiology. Renal Physiology·Vladimír PechSusan M Wall
Feb 29, 2008·American Journal of Physiology. Renal Physiology·Veerendra K Madala HalagappaCarolyn M Ecelbarger
May 19, 2017·BMC Cardiovascular Disorders·Kristoffer BernhemLena Scott
May 25, 2002·Kidney International·Annette Hus-CitharelCatherine Llorens-Cortes

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