Desensitization to oral zingerone irritation: effects of stimulus parameters

Physiology & Behavior
J Prescott, R J Stevenson

Abstract

In humans, repeated oral stimulation with the irritant capsaicin produces sensitization or desensitization, depending on the temporal relationship and, to a lesser extent, the intensity of the stimuli. We have previously shown that zingerone, an irritant present in ginger, shows only desensitization across repeated samples, as well as following a hiatus in stimulation. Because the time-course of zingerone irritation differs from that of capsaicin, it is likely that optimal temporal and other stimulation parameters may also be different. In Experiment 1, we examined the effects of stimulus intensity (0.5%, 1.0%, 2.0% zingerone) and the number of successive stimuli in a series on psychophysical responses to zingerone irritation within the series and following a 5-min hiatus. Experiment 2 examined the effect of the duration of this hiatus on desensitization and recovery. Desensitization was apparent across the initial series of stimuli in both experiments and, irrespective of zingerone concentration, in Experiment 1. Desensitization also occurred following the 5-min hiatus, evident primarily at the higher concentrations. Preceding the hiatus with 5 or 10 stimuli produced the greatest posthiatus desensitization, but a decrease in r...Continue Reading

References

Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
Apr 1, 1991·Physiology & Behavior·T Karrer, L Bartoshuk
Apr 1, 1990·Physiology & Behavior·C W Nasrawi, R M Pangborn
Dec 1, 1994·Chemical Senses·R J Stevenson, J Prescott
Dec 1, 1994·Physiology & Behavior·L M BartoshukI J Miller

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Citations

Nov 12, 1998·Physiology & Behavior·B G Green, H Rentmeister-Bryant
Jul 15, 1999·Physiology & Behavior·J Prescott
Apr 3, 2007·Chemical Senses·Mark A AffeltrangerCarey D Balaban
Feb 18, 2016·Advances in Pharmacological Sciences·Gregory Smutzer, Roni K Devassy
Apr 4, 2006·Physiology & Behavior·Margriet Westerterp-PlantengaAngelo Tremblay
Oct 1, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S ChrubasikB D Roufogalis
Aug 4, 2015·Chemosensory Perception·Nadia ByrnesJohn E Hayes
May 24, 2019·Physiology & Behavior·Alissa A NoldenJohn E Hayes
Aug 9, 2006·Behavioral and Brain Functions : BBF·Chi-Sang Poon, Daniel L Young

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