PMID: 3773645Nov 17, 1986Paper

Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections

Life Sciences
R S CordeiroB B Vargaftig

Abstract

The intraplantar injection of PAF-acether (PAF), induced acute oedema in the rat paw, and desensitized it to subsequent challenges with the same agonist, but not to serotonin. The desensitization was maximal (up to 80% of initial response) after seven consecutive daily injections. In this condition, PAF-induced oedema of the contralateral paw was maintained. The analogue 2-methyl carbamate-PAF (2MC-PAF) was more effective than PAF as a desensitizing agent. Furthermore, the PAF-desensitized paw was refractory to challenges with 2-MC and vice-versa. PAF-acether, but not serotonin-induced rat paw oedema was inhibited by previous intravenous injection of PAF. Intravenous injections of serotonin were also effective in inhibiting selectively serotonin-induced paw oedema, but it was not possible to induce desensitization by repeated intraplantar injections of serotonin. Desensitization to PAF or the pre-treatment with the PAF antagonist BN 52021 did not block the edematogenic response induced by carrageenan.

References

Sep 1, 1979·The Journal of Pharmacy and Pharmacology·S H Ferreira
Aug 30, 1985·Biochemical and Biophysical Research Communications·I Maridonneau-PariniB B Vargaftig
Nov 1, 1983·British Journal of Pharmacology·J MorleyW Paul
Sep 1, 1981·The American Journal of Physiology·S R FindlayR N Pinckard

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Citations

Mar 1, 1989·Agents and Actions·H A Trebien, J B Calixto
Aug 1, 1988·Agents and Actions·F Q CunhaS H Ferreira
Dec 7, 1995·Biochimica Et Biophysica Acta·T Izumi, T Shimizu
Apr 29, 1987·European Journal of Pharmacology·M A MartinsB B Vargaftig
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·H C Castro-Faria-NetoL Morhy
Jul 16, 2003·Journal of Ethnopharmacology·Rattima JeenapongsaKampon Sriwatanakul
Jan 1, 1990·British Journal of Pharmacology·M G HenriquesB B Vargaftig
Feb 1, 1989·British Journal of Pharmacology·M A MartinsB B Vargaftig
Jun 18, 2005·Memórias do Instituto Oswaldo Cruz·Hugo C Castro Faria NetoGuy A Zimmerman
Mar 1, 1990·The Journal of Pharmacy and Pharmacology·H C Castro-Faria-NetoB B Vargaftig

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