Desensitizing GABAC receptors on carp retinal bipolar cells

Neuroreport
M H HanX L Yang

Abstract

Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations of GABA. Both the time constant tau of the GABAC current decay and the extent of desensitization were significantly different from that of GABAC receptors previously observed in other retinas and elsewhere in the CNS, suggesting that the GABAC receptors of carp bipolar cells might be distinct in intracellular mechanisms and subunit composition.

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Citations

Apr 5, 2001·Progress in Retinal and Eye Research·S A Bloomfield, R F Dacheux
Apr 30, 2008·Visual Neuroscience·Victoria P ConnaughtonAnna M Bender
Nov 18, 2010·Visual Neuroscience·V P Connaughton
Dec 14, 1999·The European Journal of Neuroscience·Y ShenX L Yang
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Martínez-TorresR Miledi
Mar 15, 2000·Neuroreport·D Wu, P H Zhu
Mar 28, 2003·The Journal of Biological Chemistry·Katia Gamel-DidelonArtur Mayerhofer

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