PMID: 3769450Jan 1, 1986Paper

Desferrioxamine reduces susceptibility to lipid peroxidation in rabbit kidneys subjected to warm ischaemia and reperfusion

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
C J GreenB J Fuller

Abstract

Rabbit kidneys were clamped and subjected to warm ischaemia for 60 or 120 min then reperfused with blood for 60 min or for 24 hr. Treated rabbits received desferrioxamine at 15 or 50 mg/kg i.v. 15 min before reperfusion. Their kidneys were then removed and assayed for phospholipid Schiff base fluorescence (ex. 360 nm, em. 435 nm), diene and triene conjugates by UV spectrophotometry (240 nm and 268 nm respectively), for superoxide dismutase and for reduced and oxidised glutathione to provide an index of glutathione redox activity. All indices of lipid peroxidation were significantly elevated in untreated rabbits and glutathione redox activity was reduced. Treatment with desferrioxamine however effectively prevented these deviations and in many cases maintained them at the levels in fresh rabbit kidneys. These data provide further evidence that lipid peroxidation occurring during the reperfusion period is superimposed on the damage set up during warm ischaemia and may be preventable by administration of suitable therapeutic agents.

References

Jan 1, 1979·Clinical Science·J Lunec, T L Dormandy
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C J GreenB J Fuller
Apr 10, 1982·British Medical Journal·B ModellD J Weatherall
May 8, 1982·British Medical Journal·J A Murray

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Citations

Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
Apr 1, 1993·Atherosclerosis·A N KlimovN P Teryukova
Dec 1, 1994·Free Radical Biology & Medicine·M S Paller, B E Hedlund
Feb 1, 1997·Transplantation Proceedings·J M Grinyó
Nov 26, 2002·Free Radical Biology & Medicine·Nimesh S A PatelChristoph Thiemermann
Jul 31, 2010·Dermatology Research and Practice·David Garrod
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hong HuangAbdulla K Salahudeen
Jun 27, 2009·European Journal of Pharmacology·Wei BiLanrong Bi
Oct 18, 2018·American Journal of Physiology. Renal Physiology·Pauline ErpicumFrançois Jouret
Feb 1, 1996·The British Journal of Surgery·S C WeightM L Nicholson
Aug 19, 2020·Antioxidants & Redox Signaling·Behrouz HassanniaTom Vanden Berghe
Jul 20, 2002·The Journal of Surgical Research·Roberto Anaya-PradoPeter A Ward

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