PMID: 11605939Oct 19, 2001Paper

Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs

Anesthesiology
C Dean KurthJeffrey Golden

Abstract

Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA), as used for infant heart surgery, carry a risk of ischemic neurologic injury. Volatile anesthetics have neuroprotective properties against both global and focal ischemia at normothermia. The authors examined the hemodynamic and neuroprotective effects of desflurane in a piglet CPB-DHCA model. Twenty piglets aged 5-10 days received a desflurane- (6-9% expired) or fentanyl-based anesthetic before and during CPB (before and after DHCA). DHCA lasted 90 min at 19 degrees C brain. Cardiovascular variables (heart rate, arterial pressure, blood gases, glucose, brain temperature) were monitored. On postoperative day 2, neurologic and histologic outcomes were determined. Cardiovascular variables before, during, and after CPB were physiologically similar between groups. The desflurane group had better neurologic performance (P = 0.023) and greater postoperative weight gain (P = 0.04) than the fentanyl group. In neocortex, the desflurane group had less tissue damage (P = 0.0015) and fewer dead neurons (P = 0.0015) than the fentanyl group. Hippocampal tissue damage was less in the desflurane group (P = 0.05), but overall, neuronal cell counts in the CA1 sector of t...Continue Reading

References

May 1, 1990·Stroke; a Journal of Cerebral Circulation·C P OlingerJ R Marler
Oct 5, 1987·Neuroscience Letters·M Y GlobusP Scheinberg
Jul 1, 1995·Archives of Pediatrics & Adolescent Medicine·G MillerJ L Myers
Dec 1, 1995·British Journal of Anaesthesia·C Werner Schulte J am Esch
Nov 21, 1997·Acta Anaesthesiologica Scandinavica·W E HoffmanG Edelman
Jan 23, 1999·Anesthesia and Analgesia·V Soonthon-BrantM Watson
Feb 5, 1999·Seminars in Neurology·S L Hickenbottom, J Grotta
Feb 6, 1999·Critical Care Medicine·R D Cane, R Neymour
Dec 10, 1999·Anesthesia and Analgesia·H HaradaP M Patel
Dec 14, 1999·The Journal of Thoracic and Cardiovascular Surgery·C D KurthR Raghupathi
Apr 26, 2000·Anesthesiology·C W Whitten, P E Greilich

❮ Previous
Next ❯

Citations

Mar 26, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji-Hong XuYi-Nan Zhang
Jan 6, 2006·International Anesthesiology Clinics·Lori A Aronson, James P Spaeth
Apr 28, 2010·Artificial Organs·Xiaowei W Su, Akif Undar
Mar 31, 2010·Pediatric Research·Erin L AlbersBethann McLaughlin
Aug 24, 2005·Anesthesia and Analgesia·Lisa Wise-FaberowskiDavid S Warner
Dec 22, 2005·Anesthesia and Analgesia·Andreas W LoepkeJohn J McAuliffe
May 24, 2008·Anesthesia and Analgesia·Andreas W Loepke, Sulpicio G Soriano
May 24, 2008·Anesthesia and Analgesia·Andreas W LoepkeSulpicio G Soriano
May 24, 2008·Anesthesia and Analgesia·Vincent DegosPierre Gressens
Jul 25, 2007·Annals of Cardiac Anaesthesia·Suresh Chengode, Priya R Menon
Jun 26, 2014·Brain Sciences·Lisa Wise-FaberowskiGregory B Hammer
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Robert D SandersMervyn Maze
Nov 24, 2004·Journal of Neurosurgical Anesthesiology·David S Warner
Jun 26, 2014·Brain Sciences·Sunny Chiao, Zhiyi Zuo
Aug 26, 2009·Anesthesiology Clinics·Jimmy W Huh, Ramesh Raghupathi
Apr 4, 2015·European Journal of Pharmacology·Seong-Joo ParkJung-Hee Ryu
Nov 29, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jinping LiuCun Long
Oct 19, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideto KitanoStephanie J Murphy
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Glyn D Williams, Chandra Ramamoorthy
Oct 6, 2018·Journal of Neuroscience Methods·Antonio VinciguerraGiuseppe Pignataro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
S M LangleyR M Ungerleider
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Dominique Shum-TimRobert Platt
Seminars in Cardiothoracic and Vascular Anesthesia
Scott D MarkowitzSusan C Nicolson
© 2021 Meta ULC. All rights reserved