Desflurane, enflurane, isoflurane and ether produce ethanol-like discriminative stimulus effects in mice

Pharmacology, Biochemistry, and Behavior
S E Bowen, Robert L Balster

Abstract

In the present studies, drug discrimination procedures were used to compare the discriminative stimulus effects of ethanol (ETOH) and several volatile anesthetics. Male albino mice were trained to discriminate between IP injections of ETOH (1.25 g/kg) and saline in a two-lever operant task in which responding was under the control of a fixed-ratio 20 (FR20) schedule of food presentation. Stimulus generalization was examined after 20-min inhalation exposures to desflurane (4,000-32,000 ppm), enflurane (3,000-12,000 ppm), isoflurane (1,000-8,000 ppm) and ether (4,000-32,000 ppm). Concentration-related increases in ETOH-lever responding were observed for all four volatile anesthetics. For enflurane and ether, maximal levels of > 85% ETOH-lever responding were obtained at one or more concentrations. For desflurane and isoflurane, the maximal mean percentages of ETOH-lever responding were somewhat lower, but 6 out of 7 mice showed full substitution with desflurane and 5 out of 7 for isoflurane. The shared discriminative properties of these compounds with ETOH suggest that these anesthetics may share some of ETOH's pharmacological properties. These results are similar to previous research results showing ETOH-like discriminative stim...Continue Reading

Citations

Jun 2, 2020·World Journal of Psychiatry·Anatoly E MartynyukJia-Qiang Zhang
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas JonesSteve C R Williams
Apr 12, 2007·Behavioural Pharmacology·Keith L Shelton
May 7, 2011·Risk Analysis : an Official Publication of the Society for Risk Analysis·Vernon A BenignusWilliam K Boyes
Apr 28, 2006·Current Opinion in Psychiatry·Ty A Ridenour
Feb 4, 2010·The Journal of Pharmacology and Experimental Therapeutics·Keith L Shelton
Aug 26, 1998·Drug and Alcohol Dependence·R L Balster
Jun 5, 2021·Neurotoxicology and Teratology·Silvia L Cruz, Scott E Bowen
Dec 14, 2007·Drug and Alcohol Dependence·James P ZacnyMolly Sells

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