Desflurane induces airway contraction mainly by activating transient receptor potential A1 of sensory C-fibers.

Journal of Anesthesia
Jun-ichi Satoh, M Yamakage

Abstract

We previously reported that desflurane induced airway contraction via antidromic tachykinin release from sensory C-fibers. Here, we investigated the effect of desflurane on airway lung resistance (R(L)) using specific receptor antagonists in C-fibers. Young guinea pigs were anesthetized and their tracheas were cannulated with an endotracheal tube via a tracheotomy. A Fleisch pneumotachograph and a differential transducer were used to monitor respiratory flow rate, intrapleural pressure, and airway pressure, and R(L) was calculated and recorded. A transient receptor potential A1 (TRPA1) or a transient receptor potential V1 (TRPV1) selective antagonist of sensory C-fibers, i.e., HC030031 or BCTC, was administered before the exposure to desflurane. In an additional experiment, tachykinin receptor of airway smooth muscles was antagonized only by the neurokinin-2 receptor antagonist MEN-10376 before the exposure to desflurane. HC030031 completely inhibited both the first and the second contractile responses induced by desflurane, whereas BCTC had little effect. MEN-10376 also significantly and substantially diminished the contractile response. Desflurane contracts the airway in untreated guinea pigs mainly by activating irritant gas...Continue Reading

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Citations

Aug 26, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Charles W Emala
Sep 3, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Carole F MyersWalid Habre
Mar 24, 2011·Future Medicinal Chemistry·Jason C RechAlan D Wickenden
Oct 2, 2012·Annual Review of Physiology·Diana M BautistaMakoto Tsunozaki
May 16, 2014·International Urogynecology Journal·Akira FurutaNaoki Yoshimura
Aug 2, 2011·Nature Reviews. Drug Discovery·Magdalene M MoranArpad Szallasi
May 27, 2010·Anesthesiology·George Gallos, Pamela Flood
Apr 25, 2013·Anesthesiology·Mohamed Tiouririne, Carl Lynch
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Oct 4, 2019·Human & Experimental Toxicology·C D Lindsay, C M Timperley
Jun 6, 2013·European Journal of Anaesthesiology·Walid Habre, Ferenc Petak
Apr 14, 2012·Current Opinion in Anaesthesiology·Karin Becke
Jun 26, 2020·Molecular Pharmacology·Hoai T TonGerard P Ahern
Mar 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hoai T TonGerard P Ahern
Feb 20, 2021·Experimental Biology and Medicine·Maria A OliveiraRenato L Vitorasso

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