Desflurane pharmacokinetics during cardiopulmonary bypass

Journal of Cardiothoracic and Vascular Anesthesia
B MetsS Park

Abstract

To describe the washin and washout of desflurane when first administered during cardiopulmonary bypass (CPB) for cardiac surgery. A single-arm prospective study. University-affiliated hospital operating room. Ten adult patients presenting for cardiac surgery. Consenting patients presenting for cardiac surgery received anesthesia with midazolam and fentanyl. Patients were cooled to 32 degrees C on CPB, then desflurane 6% was administered and blood samples drawn repeatedly from the arterial and venous bypass cannulae as well as from the membrane oxygenator inlet and exhaust from 2 to 32 minutes of desflurane administration. Just before rewarming, final (maximum) washin samples were taken. On rewarming, desflurane was discontinued, and blood and gas samples were taken 2 to 24 minutes thereafter. CPB time was 116 +/- 10 minutes, and ischemic time was 81 +/- 6 minutes. Mean pump flow was 4.49 +/- 0.03 L/min, and mean arterial pressure was 70.1 +/- 1 mmHg during the study period. Arterial washin of desflurane was initially rapid; arterial concentrations reached 50% of administered concentrations within 4 minutes, but then slowed, reaching 68% of inspired concentrations at 32 minutes (desflurane concentration 4.0% +/- 0.3%). Arterial ...Continue Reading

Citations

Mar 12, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Roberta MeroniElena Bignami
Mar 20, 2015·Anesthesia and Analgesia·Aaron E BarryMartin J London
Jan 23, 2016·Anesthesia and Analgesia·Rainer NitzschkeMatthias Sebastian Goepfert
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Richard I Hall

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