Desflurane reduces the effective therapeutic infusion rate (ETI) of cisatracurium more than isoflurane, sevoflurane, or propofol

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Thomas M HemmerlingH Schwilden


The present study investigated the interaction between the cumulative dose requirements of cisatracurium and anesthesia with isoflurane, sevoflurane, desflurane or propofol using closed-loop feedback control. Fifty-six patients (18-85 yr, vitrectomies of more than one hour) were studied. In the volatile anesthetics groups, anesthesia was maintained by 1.3 MAC of isoflurane, sevoflurane or desflurane; in the propofol group, anesthesia was maintained by a continuous infusion of 6-8 propofol. After bolus application of 0.1 cisatracurium, a T1%-level of 10% of control level (train-of-four stimulation every 20 sec) was maintained using closed-loop feedback controlled infusion of cisatracurium. The effective therapeutic infusion rate (ETI) was estimated from the asymptotic steady-state infusion rate Iss. The Iss was derived from fitting an asymptotic line to the measured cumulative dose requirement curve. The ETI of the different groups was compared using Kruskal-Wallis- test, followed by rank sum test, corrected for the number of comparisons, P <0.05 was regarded as showing significant difference. ETI in the isoflurane group was 35.6 +/- 8.6 microg.m(-2).min(-1), in the sevoflurane group 36.4+/- 11.9 micro...Continue Reading


Jan 1, 1992·Journal of Clinical Anesthesia·A F Ghouri, P F White
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·K S Khuenl-BradyR D Miller
Jul 1, 1991·Acta Anaesthesiologica Scandinavica·K T OlkkolaC Apffelstaedt
Feb 1, 1991·Anesthesiology·D A O'HaraB E Marshall
Feb 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Kansanaho, K T Olkkola
Jun 1, 1996·Journal of Clinical Anesthesia·T J GanP S Glass
Feb 1, 1996·British Journal of Anaesthesia·W W Mapleson

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