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Design and analysis of admixture mapping studies

American Journal of Human Genetics

Apr 17, 2004

Clive J HoggartP M McKeigue

Abstract

Admixture between populations originating on different continents can be exploited to detect disease susceptibility loci at which risk alleles are distributed differentially between these populations. We first examine the statistical power and mapping resolution of this approach in the ...read more

Mentioned in this Paper

African Continental Ancestry Group
Genetics, Population
Genetic Markers
Genome Mapping
Gametes
Genetic Equilibrium
Rare Diseases
Two-Parameter Models
Locus
Alleles
210
2
Paper Details
References
  • References12
  • Citations191
12
  • References12
  • Citations191
12345...

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Design and analysis of admixture mapping studies

American Journal of Human Genetics

Apr 17, 2004

Clive J HoggartP M McKeigue

PMID: 15088268

DOI: 10.1086/420855

Abstract

Admixture between populations originating on different continents can be exploited to detect disease susceptibility loci at which risk alleles are distributed differentially between these populations. We first examine the statistical power and mapping resolution of this approach in the ...read more

Mentioned in this Paper

African Continental Ancestry Group
Genetics, Population
Genetic Markers
Genome Mapping
Gametes
Genetic Equilibrium
Rare Diseases
Two-Parameter Models
Locus
Alleles
210
2

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

American Journal of Human Genetics

Methods for high-density admixture mapping of disease genes(opens in new tab)

American Journal of Human GeneticsApril 17, 2004
Nick PattersonDavid Reich
American Journal of Human Genetics

Control of confounding of genetic associations in stratified populations(opens in new tab)

American Journal of Human GeneticsJune 24, 2003
Clive J HoggartP M McKeigue
Paper Details
References
  • References12
  • Citations191
12
  • References12
  • Citations191
12345...

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