Design and analysis of fMRI studies with neurologically impaired patients.

Journal of Magnetic Resonance Imaging : JMRI
Cathy J PriceKarl J Friston

Abstract

Functional neuroimaging can be used to characterize two types of abnormality in patients with neurological deficits: abnormal functional segregation and abnormal functional integration. In this paper we consider the factors that influence the experimental design, analysis, and interpretation of such studies. With respect to experimental design, we emphasize that: 1) task selection is constrained to tasks the patient is able to perform correctly, and 2) the most sensitive designs entail presenting stimuli of the same type close together. In terms of data preprocessing, prior to statistical analysis, we note that structural pathology may call for constraints on nonlinear transformations, used by spatial normalization, to prevent distortion of intact tissue. This means that one may have to increase spatial smoothing to reduce the impact of inaccurate normalization. Important issues in statistical modeling concern the first level of analysis (estimation of activation within subject), which has to distinguish correct from incorrect responses. At the second level (between subjects), inference should be based on between-subjects variance. Provided that these and other constraints are met, deficits in functional segregation are indicat...Continue Reading

References

Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak
Apr 1, 1992·Brain : a Journal of Neurology·K J FristonR S Frackowiak
Sep 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C D FrithP F Liddle
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Nov 5, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D D MillerR D Hichwa
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Oct 1, 1996·NeuroImage·K J FristonR J Dolan
Mar 17, 1998·NeuroImage·K J FristonR Turner
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·B HorwitzB C Donohue
Mar 3, 1999·Clinical and Experimental Hypertension : CHE·V Shantaram
Dec 22, 1999·Nature Neuroscience·E PaulesuU Frith
Mar 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S J NeeleJ C Netelenbos
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·R PineiroP M Matthews
Jan 30, 2002·Current Psychiatry Reports·Mitchell S NoblerHarold A Sackeim
Jul 13, 2002·Biological Psychiatry·Bennett A ShaywitzJohn C Gore
May 24, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Jun 14, 2003·Brain : a Journal of Neurology·Uta NoppeneyCathy J Price
Sep 2, 2003·NeuroImage·K J FristonW Penny
Sep 4, 2003·Annals of Neurology·S Catrin BlankRichard J S Wise
Nov 5, 2003·Nature Reviews. Neuroscience·Mark D'EspositoAdam Gazzaley
Jun 12, 2004·Cerebral Cortex·Andrea MechelliAlumit Ishai
Oct 7, 2004·Current Opinion in Neurobiology·Klaas E StephanKarl J Friston
Oct 27, 2004·NeuroImage·Richard B BuxtonThomas T Liu
Dec 3, 2004·Brain : a Journal of Neurology·Eamon J McCroryCathy J Price

❮ Previous
Next ❯

Citations

Feb 27, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Marc WermkeAlexander Drzezga
Jun 26, 2008·Journal of the International Neuropsychological Society : JINS·Frank G Hillary
May 10, 2013·Journal of the International Neuropsychological Society : JINS·E J BryerFrank G Hillary
Jan 31, 2013·Seminars in Neurology·Daniel A OrringerAlexandra J Golby
Nov 22, 2008·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Dec 9, 2008·Brain : a Journal of Neurology·J MbwanaW D Gaillard
Nov 12, 2009·Brain : a Journal of Neurology·Jane E WarrenRichard J S Wise
Feb 1, 2011·Brain : a Journal of Neurology·Lorraine K TylerEmmanuel A Stamatakis
May 17, 2011·Brain : a Journal of Neurology·Frank G HillaryDavid C Good
May 18, 2011·Brain : a Journal of Neurology·Céline R GillebertRik Vandenberghe
Aug 16, 2011·Brain : a Journal of Neurology·David J SharpRobert Leech
May 18, 2013·Brain : a Journal of Neurology·Emmanuel CarreraJean-Claude Baron
Sep 24, 2009·BMC Neuroscience·Ricarda MenkeCaterina Breitenstein
Jul 26, 2012·Journal of Neuroengineering and Rehabilitation·Federico NocchiEnrico Castelli
Dec 17, 2009·PloS One·Toru NakamuraBharat B Biswal
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen M WilsonMaria Luisa Gorno-Tempini
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sinéad L MullallyEleanor A Maguire
Feb 13, 2016·Frontiers in Human Neuroscience·Paulo BrancoStefan Sunaert
Apr 9, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F G HillaryG R Wylie
Dec 22, 2010·Brain Research·Juan-Carlos BustamanteCésar Avila
Apr 20, 2010·Experimental Neurology·Carlo TessaMario Mascalchi
Aug 23, 2008·Biological Psychiatry·Cameron S CarterStephen Strother
Apr 16, 2008·Journal of the American Geriatrics Society·Michele L RiesSterling C Johnson
Dec 4, 2014·Human Brain Mapping·Michele VeldsmanAmy Brodtmann
Oct 7, 2015·Frontiers in Neurology·Kathleen A GarrisonLisa S Aziz-Zadeh
Mar 6, 2012·NeuroImage·Marcus MeinzerUNKNOWN Neuroimaging in Aphasia Treatment Research Workshop
Jul 7, 2010·Neuropsychologia·Cynthia K ThompsonTodd B Parrish
Sep 2, 2009·Neuropsychologia·Eleanor A MaguireMichael D Kopelman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.