Design and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give?

Therapeutic Advances in Drug Safety
Manisha Juthani-Mehta, Heather G Allore

Abstract

This perspective review considers analytic features of the design of a longitudinal trial regarding antimicrobial therapy in older terminal cancer patients receiving palliative care. We first overview antimicrobial use at the end of life; both the potential hazards and benefits. Antimicrobial prescribing should consider both initiation as well as cessation of medications when analyzing the burden of medications. Approaches to decision making regarding antimicrobial use are presented and the importance of health literacy in these decision processes. We next present aspects of both feasibility and comparative trial design with a health literacy intervention to reduce antimicrobial use in older terminal cancer patients receiving palliative care. Considerations to clustered randomization and given that infections can reoccur over a trial period, we share suggestions of longitudinal modeling of clustered randomized trial data.

References

Sep 1, 1995·Journal of General Internal Medicine·N A Christakis, D A Asch
Nov 9, 2000·Journal of Pain and Symptom Management·L VitettaA Sali
Sep 27, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Liang-Kung ChenTzen-Wen Chen
May 3, 2003·Journal of Pain and Symptom Management·Patrick H WhiteRudolph M Navari
Sep 2, 2004·Biometrics·Lei LiuXuelin Huang
Aug 30, 2005·Journal of Pain and Symptom Management·Raquel E ReinboltRudolph M Navari
Dec 27, 2005·Journal of Pain and Symptom Management·Po Tin LamMan Wai Leung
Jan 31, 2006·European Journal of Cancer Care·D Y OhN K Kim
Feb 27, 2008·Archives of Internal Medicine·Erika D'Agata, Susan L Mitchell
Jul 1, 2008·Journal of Palliative Medicine·Angelo E VolandesLisa Lehmann
Dec 5, 2009·The American Journal of Medicine·Sarah N HilmerUNKNOWN Health ABC Study
Dec 5, 2009·The American Journal of Hospice & Palliative Care·Erin Diviney ChunPreeti N Malani
Jun 29, 2010·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Merav Ben NatanIrit Shachar
Jan 1, 2009·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·Stuart R LipsitzSteven Lipshultz
Jan 29, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stephanie StielFrank Elsner
Nov 11, 2011·Journal of Pain and Symptom Management·Vincent ThaiKonrad Fassbender
Jan 6, 2012·The American Journal of Hospice & Palliative Care·Andrew J ThompsonPreeti N Malani
Apr 17, 2012·Clinics in Geriatric Medicine·Danijela GnjidicSarah N Hilmer
Nov 9, 2012·Evidence-based Medicine·Ian A ScottCharles A Mitchell
Jan 16, 2013·Journal of Pain and Symptom Management·Jennifer S AlbrechtJon P Furuno
Oct 25, 2013·Journal of Palliative Medicine·Joseph H RosenbergJon P Furuno
Nov 13, 2013·Journal of Palliative Medicine·An-Hsuan ChihTai-Yuan Chiu
Jun 19, 2014·The American Journal of Hospice & Palliative Care·Chien-An YaoLong-Teng Lee
Jul 9, 2014·Antimicrobial Agents and Chemotherapy·Jon P FurunoErik K Fromme
Apr 9, 2015·Journal of the American Geriatrics Society·Heidi J Zapata, Vincent J Quagliarello
Oct 2, 2015·JAMA : the Journal of the American Medical Association·Manisha Juthani-MehtaSusan L Mitchell
Nov 5, 2015·Journal of the American Geriatrics Society·Lisa L DwyerJoseph W Shega
Nov 29, 2015·Journal of the American Geriatrics Society·Alyssa B DufourSusan L Mitchell
Dec 8, 2015·Expert Review of Anti-infective Therapy·Jon P FurunoErik K Fromme
Mar 13, 2016·The American Journal of Emergency Medicine·Travis D OlivesJames R Miner
Apr 16, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tamar F BarlamKavita K Trivedi
Jun 17, 2016·Journal of Palliative Medicine·Susan E MerelPaul S Pottinger
Aug 21, 2016·Journal of General Internal Medicine·Michael S WolfAlastair J J Wood
Oct 29, 2017·Infectious Disease Clinics of North America·Adam Baghban, Manisha Juthani-Mehta
Feb 13, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Christopher E GawJulia E Szymczak

❮ Previous
Next ❯

Citations

Jun 23, 2020·Journal of Hospice and Palliative Nursing : JHPN : the Official Journal of the Hospice and Palliative Nurses Association·Molly SinertBridget McCrate Protus
Nov 12, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alexandre R MarraEli N Perencevich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Issue Brief : a Monthly Publication From the Public Policy Institute of AARP
Joyce Dubow
Journal of Cancer Education : the Official Journal of the American Association for Cancer Education
Sheryl Ness
Journal of Pain & Palliative Care Pharmacotherapy
Arthur G Lipman
© 2022 Meta ULC. All rights reserved