Design and characterisation of doxorubicin-releasing chitosan microspheres for anti-cancer chemoembolisation

Journal of Microencapsulation
Jung Min ParkJaehwi Lee

Abstract

The aims of this study were to design and characterise doxorubicin-loaded chitosan microspheres for anti-cancer chemoembolisation. Doxorubicin-loaded chitosan microspheres were prepared by emulsification and cross-linking methods. Doxorubicin-chitosan solution was initially complexed with tripolyphosphate (TPP) to improve drug loading capabilities. Doxorubicin-loaded chitosan microspheres were highly spherical and had approximately diameters of 130-160 µm in size. Drug loading amount and loading efficiency were in the range 3.7-4.0% and 68.5-85.8%, respectively, and affected by TPP concentration, drug levels and cross-linking time. Doxorubicin release was affected by TPP complexation, cross-linking time and release medium. Especially, lysozyme in release media considerably increased drug release. Synergistic anti-cancer activities of doxorubicin-releasing chitosan microspheres were confirmed to VX2 cells in the rabbit auricle model compared with blank microspheres. Doxorubicin-loaded chitosan microspheres can efficiently be prepared by TPP gelation and cross-linking method and developed as multifunctional anti-cancer embolic material.

References

Feb 1, 1995·International Journal of Biological Macromolecules·H IshiiT Mitani
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·D B LeeperL Tupchong
Jan 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·S PäuserK Keller
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S R JameelaA Jayakrishnan
Oct 12, 1999·International Journal of Biological Macromolecules·O A Monteiro, C Airoldi
Jun 27, 2000·International Journal of Pharmaceutics·X Z Shu, K J Zhu
Feb 13, 2001·International Journal of Pharmaceutics·H Fan, A K Dash
Mar 20, 2001·Journal of Microencapsulation·X Z Shu, K J Zhu
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K A JanesM J Alonso
Nov 23, 2001·Journal of Biomaterials Science. Polymer Edition·F L MiH W Sung
Dec 14, 2002·International Journal of Pharmaceutics·Yongmei Xu, Yumin Du
Oct 8, 2003·The Oncologist·Keith Stuart
Oct 20, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil A AgnihotriTejraj M Aminabhavi
Jan 27, 2006·International Journal of Pharmaceutics·Lian-Yan WangGuang-Hui Ma
Feb 25, 2006·International Journal of Pharmaceutics·Anil K AnalCarmen Remuñán-López
Mar 7, 2006·Journal of Vascular and Interventional Radiology : JVIR·Andrew L LewisPeter W Stratford
Jun 27, 2006·AAPS PharmSciTech·Devika R Bhumkar, Varsha B Pokharkar
Dec 7, 2007·International Journal of Pharmaceutics·Changguang WangShixiang Hou
Feb 28, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shweta R UrvaJoseph P Balthasar
Jan 21, 2010·Cardiovascular and Interventional Radiology·Kwang-Hun LeeJean-Francois H Geschwind
Mar 2, 2010·Chemical & Pharmaceutical Bulletin·Myung Joo KangJaehwi Lee

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Citations

May 4, 2013·Journal of Microencapsulation·Taylan OzerkanNesrin Hasirci
Jun 25, 2016·Journal of Microencapsulation·Ailar TupalHamed Hamishehkar
Mar 4, 2017·Marine Drugs·Seong-Chul HongJaehwi Lee
Aug 6, 2013·Journal of Biomaterials Science. Polymer Edition·Hyeongmin KimJaehwi Lee
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Jan 18, 2014·Advanced Healthcare Materials·Adolfo López-NoriegaEduardo Ruiz-Hernández
Aug 25, 2018·BioMed Research International·Hong-Li YuWei-Fen Zhang

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