Design and characterization of a composite material based on Sr(II)-loaded clay nanotubes included within a biopolymer matrix

Journal of Colloid and Interface Science
Stefano Del BuffaPiero Baglioni

Abstract

This paper reports on the preparation, characterization, and cytotoxicity of a hybrid nanocomposite material made of Sr(II)-loaded Halloysite nanotubes included within a biopolymer (3-polyhydroxybutyrate-co-3-hydroxyvalerate) matrix. The Sr(II)-loaded inorganic scaffold is intended to provide mechanical resistance, multi-scale porosity, and to favor the in-situ regeneration of bone tissue thanks to its biocompatibility and bioactivity. The interaction of the hybrid system with the physiological environment is mediated by the biopolymer coating, which acts as a binder, as well as a diffusional barrier to the Sr(II) release. The degradation of the polymer progressively leads to the exposure of the Sr(II)-loaded Halloysite scaffold, tuning its interaction with osteogenic cells. The in vitro biocompatibility of the composite was demonstrated by cytotoxicity tests on L929 fibroblast cells. The results indicate that this composite material could be of interest for multiple strategies in the field of bone tissue engineering.

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Citations

Aug 19, 2015·Colloids and Surfaces. B, Biointerfaces·Duccio TatiniPiero Baglioni
Jun 10, 2016·Colloids and Surfaces. B, Biointerfaces·Stefano Del BuffaPiero Baglioni
Aug 17, 2016·Nanomedicine·Rawil F Fakhrullin, Yuri M Lvov
Oct 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina MassaroSerena Riela

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