Design and characterization of a human milk product for the preterm infant

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
Charles CzankPeter E Hartmann

Abstract

It is necessary to fortify human milk to promote optimal growth of the very preterm infant. However, the addition of non-human milk components to human milk is not ideal because of the risk of feeding intolerance and necrotizing enterocolitis. Human milk products (HMP) are an alternative to commercially available fortifiers, but their preparation is likely to result in modifications to the qualities of human milk. Ten batches of HMP were prepared with the aim of meeting a desired protein:energy ratio of 3.0 g of protein/100 kcal. Ultrafiltration was used to produce a skim milk concentrate, to which cream was then added to produce the final HMP. Characterization of HMP and human milk fortified with commercial human milk fortifiers (Nutriprem [Cow & Gate, Limerick, Ireland] and S-26 SMA human milk fortifier [Wyeth Nutrition, Baulkham Hills, NSW, Australia]) included quantifying macronutrient content, osmolality, microbial content, and particle distribution. Average protein:energy ratio of the final batch was 2.93 +/- 0.10 g of protein/100 kcal, equating to an inaccuracy of 2.5% relative to the desired ratio of 3.0 g of protein/100 kcal. Significantly greater fat (P < 0.01), lower lactose (P < 0.001), and lower osmolality (P < 0.0...Continue Reading

References

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Citations

Mar 13, 2012·Maternal & Child Nutrition·Elaine BurnsVirginia Schmied
May 9, 2012·Journal of Korean Medical Science·Seung-Yeon KimYang Cha Lee-Kim
Jul 30, 2014·Iranian Red Crescent Medical Journal·Hassan BoskabadiFarzaneh Rezagholizade Omran
Jun 17, 2020·Public Health Nutrition·Katherine BlackshawRichard B Banati

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