Design and characterization of a laminar flow-through dissolution apparatus: Comparison of hydrodynamic conditions to those of common dissolution techniques

Pharmaceutical Development and Technology
Kristyn GrecoRobin Bogner

Abstract

A flow-through dissolution apparatus was designed and evaluated to screen small quantities of pharmaceutical drug compounds early in development. The apparatus was designed to mount on a microscope slide such that a compacted solid drug was positioned flush along one wall and the fluid flow in the apparatus was laminar flow in a rectangular duct. Stereomicroscopic digital images and Raman spectra of the solid were taken during dissolution and the effluent dissolution medium was collected in fractions to determine the dissolution rate by fluorescence or HPLC/UV. Three compounds, triamterene, ketoprofen, and β-naphthoic acid were investigated in the dissolution flow cell at various hydrodynamic conditions. In conditions where no solvent-mediated conversion was expected, there was a decrease in dissolution rate with time in the flow through cell that was associated with surface smoothing. This phenomenon also occurred in rotating disk experiments. In either case, the magnitude and time course of the decrease in dissolution rate with time is generally different enough to distinguish from the decrease in dissolution rate due to solvent-mediated conversion.

References

Sep 1, 1975·Journal of Pharmaceutical Sciences·A C Shah, K G Nelson
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R Löbenberg, G L Amidon
Jan 18, 2003·Journal of Pharmaceutical Sciences·Wei SunMarylee Z Southard
Jun 1, 1960·Journal of the American Pharmaceutical Association·D E WURSTER, J A SEITZ
Nov 1, 1964·Journal of Pharmaceutical Sciences·L W DITTERTD R REESE
Jul 6, 2004·International Journal of Pharmaceutics·J KukuraF J Muzzio
Dec 24, 2004·Proceedings. Biological Sciences·Anupam PalJames G Brasseur
Feb 24, 2005·International Journal of Pharmaceutics·Jennifer L BaxterFernando J Muzzio

❮ Previous
Next ❯

Citations

Jan 12, 2013·Pharmaceutical Research·Johan P BoetkerHenrik Jensen
Jan 4, 2012·Journal of Pharmaceutical Sciences·Kristyn Greco, Robin Bogner
Apr 15, 2015·Advanced Drug Delivery Reviews·Amrit PaudelJukka Rantanen
Nov 10, 2012·Pharmaceutical Development and Technology·Sarah GordonJesper Østergaard
Mar 22, 2014·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·José Raúl MedinaAdriana Miriam Domínguez-Ramírez
Feb 6, 2017·Journal of Pharmaceutical Sciences·Yan HeEdward Orton
Jan 28, 2021·Pharmaceutics·Dominik SlezionaMarkus Thommes
Feb 20, 2020·Journal of Pharmaceutical Sciences·Pooja SaneSerguei Tchessalov
Jun 4, 2011·Molecular Pharmaceutics·Johan P BoetkerJesper Østergaard
May 13, 2010·Molecular Pharmaceutics·Kristyn Greco, Robin Bogner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.