Design and characterization of biodegradable macroporous hybrid inorganic-organic polymer for orthopedic applications

Materials Science & Engineering. C, Materials for Biological Applications
Sunita PremVictorJayabalan Muthu

Abstract

We have engineered hybrid polymer products based on a hybrid inorganic-organic comacromer consisting of hydroxyapatite (HA), carboxyl terminated polypropylene fumarate (CTPPF), PEG300 and ascorbic acid (AA) as a bone graft material. The integration and the spatial distribution of HA in the polymer backbone were facilitated by silanisation and 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) coupling technique. These comacromers and crosslinked polymer products were characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM) and Raman mapping techniques. SEM and EDAX analysis substantiate high invitro bioactivity of the polymer products. SEM studies depict a distinct macroporous structure with pore size of 50 to 300μm. These crosslinked hybrid products demonstrated no significant difference in compressive moduli after 4weeks immersion in SBF. In particular, the compressive moduli were found to be comparable with that of trabecular bone. We suggest that the formation of an apatite layer on the surface of the composites deter initial degradation leading to better mechanical stability. As expected, the polymer products displayed negligible ...Continue Reading

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