Design and characterization of lisinopril-loaded superparamagnetic nanoparticles as a new contrast agent for in vitro, in vivo MRI imaging, diagnose the tumors and drug delivery system

Journal of Materials Science. Materials in Medicine
Sajjad Abbasi Pour, Hamid Reza Shaterian

Abstract

Superparamagnetic γ-Fe2O3@SiO2@lisinopril (MNPs-Lisinopril) nanoparticles are T2 and T2* negative contrast agents for magnetic resonance imaging. In this work, we report the preparation of lisinopril-coated MNPs for the first time as new T2 and T2* negative contrast agent for in vitro and in vivo MRI imaging and demonstrate the potential it simultaneously for drug delivery system, diagnose the tumors and MRI contrast agent. Measurements on the relaxivities (r1, r2and r2*) of the MNPs-Lisinopril were determined in deionized water (in vitro). Furthermore, after subcutaneous injection of the MNPs-Lisinopril into 4T1 (ATCC®CRL2539™) tumor in BALB/c mice, the relaxivities were determined by a 1.5 T MRI apparatus (in vivo). T2- and T2*-weighted MRI images of MNPs-Lisinopril showed that the MR signal intensity decreased significantly with increasing nanoparticle concentration in water. With measured r2values up to 236.66 mM-1s -1, our MNPs-Lisinopril show better performance than commercial alternatives. Also we tested drug release of Lisinopril coated MNPs at two different pHs. The MNPs- Lisinopril is a pH-sensitive drug delivery system and releases different amounts of lisinopril from MNPs-Captopril in different pHs.

References

Jul 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W R Bauer, K Schulten
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R EhlersJ F Riordan
May 1, 1988·Drug Intelligence & Clinical Pharmacy·G M Armayor, L M Lopez
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Richard BitarTimothy P Roberts
Jan 1, 2008·Small·Nastassja LewinskiRebekah Drezek
Jan 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Kin Man Ho, Pei Li
Feb 6, 2008·Journal of the American Chemical Society·Ankona DattaKenneth N Raymond
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Taigang HeDavid N Firmin
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Taigang HeDavid N Firmin
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Govind B ChavhanE Mark Haacke
Mar 17, 2010·Chemical Reviews·Angelique Louie
Jun 19, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·William E GhannMarie-Christine Daniel
Jun 22, 2013·Chemical Society Reviews·Juan GalloEric O Aboagye
Feb 4, 2014·ACS Nano·Ruben Van RoosbroeckLiesbet Lagae

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Citations

May 29, 2020·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Georgia TrikoupiMichael Patsikas

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