Design and Characterization of Topical Formulations: Correlations Between Instrumental and Sensorial Measurements

AAPS PharmSciTech
Lívia Salomão CalixtoPatrícia M B G Maia Campos

Abstract

The interaction between cosmetic emulsions and the skin's surface is an important factor to consider in the development of topical formulations. Two important ingredients in cosmetic formulations are waxes and polymers. The physical and mechanical properties of formulations directly impact the interface skin-formulation. To evaluate this interaction, it is important to study the rheology, texture, and sensory properties. In this context, the aim of the study was to evaluate the influence of waxes and polymers on the rheological behavior, texture profile, and sensorial properties of topical formulations and the correlation between these parameters. The best combination of a wax and a polymer was determined by full factorial design of experiments and applied to develop eight formulations that were tested in relation to rheological, mechanical, and sensorial properties. The polymer helps with the spreadability of the formulation, and the wax had a strong influence on the parameters related to the structure of emulsions. A correlation between these parameters was observed. This way, it was possible to compare theoretical and practical data, except between the flow index and the work of shear. Finally, it was possible to predict sen...Continue Reading

References

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Jul 12, 2007·AAPS PharmSciTech·Sheikh Shafiq-un-NabiMushir Ali
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Aug 27, 2014·Journal of Food Science·Emin Yılmaz, Mustafa Öğütcü

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Citations

Oct 12, 2019·International Journal of Cosmetic Science·Lívia Salomão CalixtoGéraldine Savary
Jul 23, 2020·International Journal of Cosmetic Science·Francine C S César, Patrícia M B G Maia Campos
Jan 5, 2020·AAPS PharmSciTech·V T P FerreiraP M B G Maia Campos
Feb 8, 2021·International Journal of Pharmaceutics·V H P InfanteM C Meinke
Mar 18, 2021·International Journal of Cosmetic Science·Victor Hugo Pacagnelli InfantePatrícia M B G Maia Campos
May 1, 2021·International Journal of Molecular Sciences·Rita CaparicaTânia Santos de Almeida
Aug 18, 2021·Advanced Drug Delivery Reviews·Michael S RobertsJeffrey E Grice
Oct 8, 2021·Pharmaceutical Development and Technology·Celia Maria Vargas da Costa BuzzoAlexsandra Conceição Apolinário

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Methods Mentioned

BETA
rheology

Software Mentioned

Rheo
Symrise
Minitab
TA
. XT plus Texture Analyzer

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