PMID: 11902655Mar 21, 2002Paper

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

Il Farmaco
R GittoA Chimirri

Abstract

2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodegenerative diseases, such as ischemia and epilepsy. We synthesized a large number of 2,3-benzodiazepine derivatives, which showed anticonvulsant properties in different seizure models and a noncompetitive blockade of AMPA receptor. This article will briefly mention our work in this field and the main SAR considerations.

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Citations

Jan 31, 2004·Il Farmaco·Rosaria GittoAlba Chimirri
Jul 14, 2012·Expert Opinion on Investigational Drugs·Emilio RussoGiovambattista De Sarro
Sep 18, 2014·PloS One·Chao-Yin ChenMichael A Rogawski
May 5, 2017·Drug Testing and Analysis·Kieran R ManchesterPeter D Maskell
Jul 21, 2017·Molecular Diversity·Tamás FöldesiMátyás Milen

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