Design and development of vitamin C-encapsulated proliposome with improved in-vitro and ex-vivo antioxidant efficacy

Journal of Microencapsulation
Elahehnaz ParhizkarShohreh Alipour

Abstract

Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert® software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. This formulation released about 90% vitamin C within 2 h and showed higher (1.7-fold) in-vitro antioxidant activity. Ex-vivo antioxidant activity was 1.9 and 1.6 times higher in brain and liver cells, respectively. A 27% reduction in malondialdehyde (MDA) level of liver cell was obtained comparing free vitamin C. Therefore, this study results suggest that the vitamin C-encapsulated proliposome powder might be an appropriate carrier for oral drug delivery of vitamin C with better antioxidant efficacy.

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Citations

Feb 26, 2020·Journal of Microencapsulation·Qizhang HuangXugang Shu
Dec 9, 2020·Antioxidants·Marco B MorelliGaetano Santulli
Dec 23, 2020·Critical Reviews in Food Science and Nutrition·T ComunianS M Jafari
Nov 5, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Amanda Costa CaritáGislaine Ricci Leonardi
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Mar 16, 2021·Journal of Microencapsulation·Varun KumarSuman Nagpal
Nov 20, 2020·International Journal of Pharmaceutics·Amanda C CaritáGislaine Ricci Leonardi

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