Abstract
Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert® software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. This formulation released about 90% vitamin C within 2 h and showed higher (1.7-fold) in-vitro antioxidant activity. Ex-vivo antioxidant activity was 1.9 and 1.6 times higher in brain and liver cells, respectively. A 27% reduction in malondialdehyde (MDA) level of liver cell was obtained comparing free vitamin C. Therefore, this study results suggest that the vitamin C-encapsulated proliposome powder might be an appropriate carrier for oral drug delivery of vitamin C with better antioxidant efficacy.
References
Feb 1, 1984·European Journal of Biochemistry·W LohmannV Penka
Aug 1, 1996·Journal of Neurochemistry·A C AndornB R Bacon
Jul 16, 2005·Journal of Microencapsulation·K G H Desai, H J Park
May 12, 2006·International Journal of Pharmaceutics·Xiao Yan-yuPing Qi-neng
Dec 13, 2006·Journal of Liposome Research·Shantha L KosarajuAndrew Lawrence
May 1, 2008·AAPS PharmSciTech·Rakhi B ShahMansoor A Khan
Dec 3, 2008·Free Radical Research·Kalavathi DasuriJeffrey N Keller
Sep 24, 2009·Cellular and Molecular Neurobiology·Carolina G FernandesMoacir Wajner
Mar 17, 2010·Journal of the Neurological Sciences·Tarsila Barros MoraesCarlos Severo Dutra-Filho
Sep 1, 2011·International Journal of Pharmaceutics·Hongyu PiaoMasahiro Goto
Nov 22, 2011·Biological Trace Element Research·Namrata GovilSuhel Parvez
Oct 3, 2013·International Journal of Molecular Sciences·Shuibing YangYaqin Hu
Jan 22, 2014·Food Chemistry·Talita A ComunianDavid A Weitz
Aug 26, 2014·BMC Research Notes·Sanjiv KumarSudarshan Ojha
Jan 28, 2015·Avicenna Journal of Medicine·Hani Abdulsattar ShakerKhalid Obeid Dhafar
Oct 13, 2015·International Journal of Pharmaceutics·Iftikhar KhanAbdelbary Elhissi
Feb 18, 2016·Journal of Pharmaceutical Sciences·Sophia Yui Kau FongAnnette Bauer-Brandl
Jul 5, 2016·Nutrition and Metabolic Insights·Janelle L DavisChristopher Bell
Citations
Feb 26, 2020·Journal of Microencapsulation·Qizhang HuangXugang Shu
Aug 30, 2020·Journal of Food Science·Fan-Fan SongBei-Bei Zhang
Dec 9, 2020·Antioxidants·Marco B MorelliGaetano Santulli
Dec 23, 2020·Critical Reviews in Food Science and Nutrition·T ComunianS M Jafari
Nov 5, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Amanda Costa CaritáGislaine Ricci Leonardi
Jan 19, 2021·BioMed Research International·Marzieh RashediniaZahra Sabahi
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Mar 9, 2021·ACS Omega·Joby JacobShintu Jude
Mar 16, 2021·Journal of Microencapsulation·Varun KumarSuman Nagpal
Nov 20, 2020·International Journal of Pharmaceutics·Amanda C CaritáGislaine Ricci Leonardi
Jul 9, 2021·BioMed Research International·Marzieh RashediniaMohammad M Zarshenas