Design and dosimetry of a facility to study health effects following exposures to fission neutrons at low dose rates for long durations

International Journal of Radiation Biology
T B BorakMichael M Weil

Abstract

Purpose: During extended missions into deep space, astronauts will be exposed to a complex radiation field that includes high linear energy transfer (LET) radiation from high energy, heavy ions (HZE particles) at low dose rates of about 0.5 mGy/d for long durations. About 20% of the dose is delivered by ions with LET greater than 10 keV/µm. There are sparse empirical data in any species for carcinogenic effects from whole-body exposures to external sources of mixed or high LET radiation at this level of dose rates. For the induction of solid tumors, acute exposures to HZE ions have been shown to be substantially more effective per unit dose than low LET exposures associated with photons. To determine the health effects of high LET radiation at space-relevant dose rates on experimental animals, we developed a vivarium in which rodents could be irradiated with Californium (252Cf) neutrons for protracted periods of time.Materials and methods: The neutron source is a panoramic irradiator containing 252Cf located in a concrete shielded vault with a footprint of 53 m2. The vault can accommodate sufficient caging to simultaneously irradiate 900 mice and 60 rats for durations up to 400 d at a dose rate of 1 mGy/d and is approved for ex...Continue Reading

References

Dec 1, 1973·Archives of Neurology·F H Anderson, J R Lehrich
Oct 4, 2012·Health Physics·Helle Bielefeldt-OhmannMichael M Weil
Sep 17, 2013·Radiation Protection Dosimetry·Weihua ZhangWei Li
Mar 8, 2016·Life Sciences in Space Research·John W NorburyCary J Zeitlin
Mar 8, 2016·Life Sciences in Space Research·Tony C SlabaChiara La Tessa
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May 19, 2019·Life Sciences in Space Research·Frederico KifferAntiño R Allen
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Citations

Nov 15, 2019·International Journal of Radiation Biology·Richard A BrittenLarry D Sanford

Related Concepts

Californium
Cell Nucleus
Cell Wall
Ions
Laboratory mice
Operating Room
Radiometry
Rodent
Spatial Distribution
Depth

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