Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection

Medical Physics
Lei XiH Jiang

Abstract

The authors present the design and evaluation of a second-generation (G2) hybrid photoacoustic tomography (PAT) and diffuse optical tomography (DOT) imaging system for detection of breast cancer. The combined PAT/DOT system takes full advantages of two different modalities to provide complementary information and most accurate recovery of tissue optical properties. This system was designed to produce cross-section images of breast tissue with a ring-shaped home-made array of 64 wideband acoustic transducers combined with an array of 16/16 source/detector optical fiber bundles. A scanning light delivery system was built to illuminate a large area of breast tissue for optimized tissue penetration. Finite element reconstruction methods for quantitative PAT and DOT were utilized to recover absorption and scattering coefficients of tissue-mimicking phantoms and ex vivo tumor tissue. Performances of the acoustic transducer array and the PAT/DOT system were investigated in detail. Frequency response of the transducers is from 380 kHz to 1.48 MHz and maximum frequency response is up to 2 MHz. Directivity of a single element in the array is ±30°. The PAT/DOT system offers a spatial resolution of ∼0.5 mm for PAT and of ∼4.0 mm for DOT. Q...Continue Reading

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Citations

Sep 10, 2014·The Breast Journal·Avice M O'ConnellSrinivasan Vedantham
Sep 4, 2015·Medical Physics·Xiaoqi LiHuabei Jiang
Apr 20, 2016·Journal of Biophotonics·Amalina Binte Ebrahim AttiaMalini Olivo
Feb 3, 2018·Journal of Medical Imaging·Michael A PinkertKevin W Eliceiri
Nov 29, 2016·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Nov 29, 2016·Journal of Biomedical Optics·Yasufumi AsaoMasakazu Toi
Oct 31, 2019·Journal of Biophotonics·Hao YangHuabei Jiang
Nov 22, 2016·Biomedical Optics Express·Valeriya PerekatovaIlya Turchin
Dec 4, 2013·Biomedical Optics Express·Wenfeng XiaSrirang Manohar
Aug 2, 2013·Optics Letters·Chaolong SongHuabei Jiang
Mar 28, 2019·Journal of Biophotonics·Jinge YangHuabei Jiang
Sep 15, 2020·Biomedical Optics Express·Jinge YangHuabei Jiang
Oct 5, 2016·Biomedical Optics Express·Na HuangLei Xi
Apr 3, 2020·Visual Computing for Industry, Biomedicine and Art·Qiwen XuHuabei Jiang
Dec 3, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Yang LouMark A Anastasio
Nov 16, 2017·Optics Letters·Heng GuoLei Xi
Dec 19, 2020·Molecular Imaging·Mucong LiJunjie Yao
Mar 4, 2018·Ultrasound in Medicine & Biology·Xiang ZhangXiaojun Liu

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