Design and evaluation of a new bioelectrical impedance sensor for micro-surgery: application to retinal vein cannulation

International Journal of Computer Assisted Radiology and Surgery
Laurent SchoevaerdtsEmmanuel Vander Poorten

Abstract

Nowadays, millions of people suffer from retinal vein occlusion, a blind-making eye disease. No curative treatment currently exists for this vascular disorder. However, a promising treatment consists in injecting a thrombolytic drug directly inside the affected retinal vessel. Successfully puncturing miniature vessels with diameters between 50 and 400 [Formula: see text] remains a real challenge, amongst others due to human hand tremor, poor visualisation and depth perception. As a consequence, there is a significant risk of double-puncturing the targeted vessel. Sub-surfacic injection of thrombolytic agent could potentially lead to severe retinal damage. A new bio-impedance sensor has been developed to visually display the instant of vessel puncture. The physical working principle of the sensor has been analysed, and a representative electrical model has been derived. Based on this model, the main design parameters were derived to maximise the sensor sensitivity. A detailed characterisation and experimental validation of this concept were conducted. Stable, repeatable and robust impedance measurements were obtained. In an experimental campaign, 35 puncture attempts on ex vivo pig eyes vessels were conducted. A confusion matrix...Continue Reading

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Citations

Sep 3, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Yao WangGuang-Biao Chen

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