Design and evaluation of a passive alcove-based microfluidic mixer.

Analytical Chemistry
Tsuyoshi EgawaSyun-Ru Yeh

Abstract

A novel passive microfluidic silicon mixer has been designed, optimized and fabricated. The architecture of the mixer consists of a simple "T" junction, made up by a 20 microm wide by 82 microm deep channel, followed by three repeats of an alcove, each with a triangular obstruction, arranged in a zigzag fashion. Numerical simulations were employed to optimize the geometry, particularly the dimensions of the alcoves, the relative orientation and the spacing between them, and the degree of intrusion associated with them. The simulation results demonstrate that chaotic flow due to recirculation within the alcoves results in transverse velocity that promotes effective fluid mixing. The microfluidic mixer with the simulation-optimized geometry was fabricated with photolithographic techniques and characterized by optical imaging, fluorescence, and Raman microscope spectroscopy. At a sample flow rate of 20 microL/s, the mixer exhibits a short mixing deadtime of approximately 22 micros and a high mixing efficiency under both low and high viscosity conditions. The alcove-based microfluidic silicon mixer offers unique advantages for its short deadtime and slow sample consumption rate. In addition, it provides a valuable component for lab...Continue Reading

References

Jan 1, 1997·Nature Structural Biology·S TakahashiD L Rousseau
Apr 20, 2001·Nature·A Groisman, V Steinberg
May 17, 2001·Analytical Chemistry·B HeF E Regnier
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·E KauffmannK Gerwert
Jan 25, 2002·Analytical Chemistry·Timothy J JohnsonLaurie E Locascio
Jan 26, 2002·Science·Abraham D StroockGeorge M Whitesides
Aug 30, 2002·Analytical Chemistry·Virginie MengeaudHubert H Girault
Oct 31, 2002·Analytical Chemistry·Abraham D StroockArmand Ajdari
Jan 9, 2004·Analytical Chemistry·Yu LinSyun-Ru Yeh
Jul 27, 2004·Science·Julio M Ottino, Stephen Wiggins
Aug 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Julio M Ottino, Stephen Wiggins
Aug 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Mark A StremlerHassan Aref
Aug 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Christopher J Campbell, Bartosz A Grzybowski
Jul 1, 2006·Analytical Chemistry·David E HertzogJuan G Santiago
Jul 1, 2006·Analytical Chemistry·Hye Yoon ParkLois Pollack

❮ Previous
Next ❯

Citations

Mar 14, 2013·Journal of Magnetic Resonance·Royi KaufmannDaniella Goldfarb
Jun 5, 2012·Journal of Environmental Sciences (China)·Shuhua XueHai-Fang Li
Oct 7, 2014·Biochimica Et Biophysica Acta·Nikolai BelevichMarina Verkhovskaya
Aug 28, 2012·Biochimica Et Biophysica Acta·Fei ZhouChang-An Yu
Jul 2, 2011·Biochimica Et Biophysica Acta·Michelle A YuGary J Gerfen
Nov 6, 2012·Current Opinion in Structural Biology·Lisa J Lapidus
May 14, 2010·Analytical Chemistry·Arun AroraAndreas Manz
Sep 3, 2020·The Journal of Physical Chemistry. a·Sunit PalErode N Prabhakaran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.