PMID: 12672600Apr 4, 2003

Design and evaluation of an aerosol infection chamber for small animals

International Journal of Pharmaceutics
Sangeeta Bhaskar, Pramod Upadhyay


In this report, we describe the design of an aerosol exposure chamber to reproducibly produce uniformly distributed clouds of droplet nuclei. The device can deliver desired number of bacilli (20-2000) in lungs of mice. All safety measures to handle infectious bacteria have been incorporated in the design and it is controlled remotely by a personal computer. It is an indispensable device to study the protective efficacy of vaccine candidates against Mycobacterium tuberculosis infection. This device would also be useful to study immunization and drug delivery by nasal route in experimental animals.


May 1, 1994·International Journal of Immunopharmacology·M Gheorghiu
Feb 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M LagranderieD W Smith
Feb 2, 1999·South Dakota Journal of Medicine·J R Heins
Nov 5, 1999·Pharmaceutical Science & Technology Today·S S Davis
Apr 5, 2001·Trends in Molecular Medicine·D N McMurray
Dec 14, 2001·AAPS PharmSci·R J PettisA J Hickey

Related Concepts

Aerosol Dose Form
Atmosphere Exposure Chambers
Mice, Inbred C57BL
Mycobacterium tuberculosis H37Rv
Tuberculosis, Pulmonary
Inhalation Exposure

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