Design and evaluation of mPEG-PLA micelles functionalized with drug-interactive domains as improved drug carriers for docetaxel delivery

Journal of Biomaterials Science. Polymer Edition
Dingqing QiChong Lu

Abstract

Polymeric micelles are very attractive drug delivery systems for hydrophobic agents, owing to their readily tailorable chemical structure and ease for scale-up preparation. However, the intrinsic poor stability of drug-loaded micelles presents one of the major challenges for most micellar systems in the translation to clinical applications. In this study, a simple, well-defined, and easy-to-scale up 9-Fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) containing lysine dendronized mPEG-PLA (mPEG-PLA-Lys(FB)2) micellar formulation was designed and prepared for docetaxel (DTX) delivery, in an effort to improve the stability of the micelles, and its physicochemical properties, pharmacokinetics, and anti-tumor efficacy against SKOV-3 ovarian cancer were evaluated. MPEG-PLA-Lys(FB)2was synthesized via a three-step synthetic route, and it actively interacted with DTX in aqueous media to form stable micelles with small particle sizes (~17-19 nm) and narrow size distribution (PI < 0.1), which can be lyophilized and easily reconstituted in saline without significant change in particle size distribution. In vitro drug-release study demonstrated that mPEG-PLA-Lys(FB)2micelles achieved delayed and sustained release manner of DTX...Continue Reading

References

Nov 6, 2003·Journal of the American Chemical Society·Yan ZhangBing Xu
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Moo HuhKinam Park
Apr 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Radoslav SavićDusica Maysinger
May 3, 2007·Journal of Biomaterials Science. Polymer Edition·Michael GoldbergXinqiao Jia
Oct 24, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Myrra G CarstensWim E Hennink
May 5, 2010·International Journal of Pharmaceutics·Gurusamy SaravanakumarKinam Park
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam
Aug 24, 2010·Drug Discovery Today·Ranjita MisraSanjeeb K Sahoo
Mar 1, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Young KimKinam Park
Jun 28, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sa-Won LeeSun-Ok Kim
Feb 7, 2013·International Journal of Pharmaceutics·Tobias MillerAchim Goepferich
Dec 30, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas WickiJörg Huwyler
Sep 19, 2015·Pharmaceutical Research·Avinash GothwalUmesh Gupta
Feb 26, 2016·Journal of Biomaterials Science. Polymer Edition·Xiaoxiong HanYaling Shen
Apr 3, 2016·International Journal of Biological Macromolecules·Kaisar RazaO P Katare
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Caixia LiYuan Le
May 25, 2016·Current Pharmaceutical Design·Pramod KumarOm Prakash Katare

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
Dynamic Light Scattering
xenograft
acylation
fluorescence spectroscopy
differential
xenografts

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.