Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures

Bioorganic & Medicinal Chemistry Letters
Kazuki ShimizuKazumi Morikawa

Abstract

Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2).

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Citations

Jul 1, 2007·Expert Opinion on Drug Discovery·Peter Buchwald
Jun 6, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Akira TakeiriMasayuki Mishima
Nov 10, 2018·Journal of Medicinal Chemistry·Benjamin JeffriesBruno Linclau

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