Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Bioorganic & Medicinal Chemistry Letters
Nilesh Shah, Thomas S Scanlan

Abstract

A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) mediated transcription in vitro, dissociating transactivation, AP-1 repression, and NF-kappaB repression from each other.

Citations

Jun 4, 2013·Nature Structural & Molecular Biology·Lisa C WatsonKeith R Yamamoto
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Mar 27, 2009·Bioorganic & Medicinal Chemistry Letters·Bingwei V YangJoel C Barrish
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Sep 11, 2021·Journal of Chemical Information and Modeling·Haiyi ChenTingjun Hou
Aug 7, 2013·Bioorganic & Medicinal Chemistry Letters·John L GilmoreJoel C Barrish
Aug 21, 2013·Bioorganic & Medicinal Chemistry Letters·James E SheppeckJoel C Barrish

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