Design and evaluation of ocular drug delivery system for controlled delivery of gatifloxacin sesquehydrate: In vitro and in vivo evaluation

Pharmaceutical Development and Technology
Upendrakumar L PatelChirag D Nagda

Abstract

The objective of this investigation was to formulate ocular inserts of gatifloxacin sesquehydrate to achieve controlled drug release. Drug reservoir was prepared using hydrophilic polymers, namely polyvinyl alcohol and polyvinyl pyrrolidone. The rate controlling membrane was prepared using hydrophobic ethyl cellulose by solvent casting method. Ocular inserts were evaluated for uniformity of weight, thickness, drug content, surface pH, percentage moisture absorption, percentage moisture loss, drug excipients compatibility, in vitro release, sterility test, eye irritation, in vivo release, microbiological and stability studies. Ocular inserts complied with all the physico-chemical parameters. Drug excipients compatibility studies demonstrated no interaction between drug and polymer. The in vitro release profile of drug from ocular inserts showed controlled and prolonged release. The release data followed zero order and non-Fickian transport. Ocular inserts passed the test for sterility. Correlation between in vitro and in vivo drug release was found to be strong revealing the efficacy of the formulation. The drug was found to be effective against Staphylococcus aureus and Escherichia coli. The result of accelerated stability stud...Continue Reading

References

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Jun 24, 2008·Current Eye Research·A S Mundada, B K Shrikhande

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Citations

Sep 24, 2020·Revista brasileira de enfermagem·Elionara Teixeira Boa Sorte FernandesEliene Almeida Santos
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak

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