Design and evaluation of soluble ocular drug insert for controlled release of ciprofloxacin hydrochloride

Drug Development and Industrial Pharmacy
A S Mundada, B K Shrikhande

Abstract

Soluble ocular inserts of ciprofloxacin hydrochloride were prepared with the aim of achieving once a day administration. Drug reservoir was prepared using natural hydrophilic polymer viz. gelatin while rate-controlling membrane was prepared using hydrophobic ethyl cellulose. Ocular inserts were evaluated for their physicochemical parameters like thickness, weight uniformity, drug content, percent moisture loss, and percent moisture absorption. The in vitro drug release studies were carried out using Bi-chambered donor receiver compartment model. Since targeted prolong release was observed in formulation CF2 and CF5, these formulations were further subjected to in vivo drug release study using rabbits as an animal model. In vitro drug release kinetic data was treated according to Zero, First, and Higuchi kinetics to access the mechanism of drug release. Correlation between in vitro and in vivo drug release was found to be strong revealing the efficacy of the formulation. Formulation CF5 has achieved target of present study such as increase residence time, prolong drug release, reduction in frequency of administration, and, thus may improve the patient compliance.

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Citations

Apr 29, 2014·TheScientificWorldJournal·Przemysław BaranowskiJanusz Pluta
Mar 17, 2015·Translational Vision Science & Technology·Juan-Carlos Gutiérrez-HernándezMark Humayun
Mar 31, 2009·Expert Opinion on Drug Delivery·Thirumurthy Velpandian
Feb 20, 2013·Expert Opinion on Drug Delivery·Pravin PawarDipak K Majumdar
Jun 27, 2009·Drug Development and Industrial Pharmacy·A S Mundada, J G Avari
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Jun 24, 2008·Current Eye Research·A S Mundada, B K Shrikhande
Jan 17, 2016·Macromolecular Bioscience·Kambiz FarbodSander C G Leeuwenburgh
Jun 26, 2009·Pharmaceutical Development and Technology·Ashish Prakash Gorle, S G Gattani
Jan 19, 2018·Pharmaceutics·Marion DubaldHatem Fessi
Mar 18, 2008·Journal of Glaucoma·Deepta Ghate, Henry F Edelhauser
Sep 2, 2009·Chemical & Pharmaceutical Bulletin·Ashish Prakash Gorle, Suredra Ganeshlal Gattani
Nov 15, 2017·Drug Delivery and Translational Research·María Sebastián-MorellóAlicia López-Castellano
Jul 31, 2020·Drug Delivery and Translational Research·Hamdia G WafaGamal M El Maghraby
Jul 26, 2021·International Journal of Pharmaceutics·Adrián M Alambiaga-CaravacaAlicia López-Castellano

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