PMID: 9434292Jan 22, 1998Paper

Design and experimental verification of thin acoustic lenses for the coagulation of large tissue volumes

Physics in Medicine and Biology
T FjieldKullervo Hynynen

Abstract

Large focal volumes are desired in ultrasound surgery to reduce the total treatment time when large tumours are thermally coagulated. Phased arrays are capable of producing enlarged focal volumes in addition to providing the ability for on-line modification of focal shape and location. Although phased arrays have several advantages over their non-phased counterparts, the complexity of these arrays also presents some disadvantages regarding cost and complexity. One less costly alternative is the use of thin acoustic lenses to alter the field shape of a single-focus transducer. Four polystyrene lenses have been designed using the sector-vortex principle developed for phased arrays by Cain and Umemura. Measurements of the acoustic fields produced with the lenses are in good agreement with the simulated fields. The transmission measurements through each of the four lenses ranged from 76% to 84%, and over 52 W of total acoustic power has been delivered through each of the lenses during in vivo experiments without any damage to the lenses or the transducer. The in vivo results showed an increase in rate of necrosis to 10.1 +/- 1.4 cm3 h-1 using the mode 4 lens, or 5.2 +/- 0.7 times higher than the focused transducer alone.

References

May 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S I Umemura, C A Cain
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Citations

Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·N McDannoldF Jolesz
Mar 21, 1998·Journal of Magnetic Resonance Imaging : JMRI· McDannoldF Jolesz
Aug 16, 2000·Ultrasound in Medicine & Biology·N VykhodtsevaK Hynynen
Apr 11, 2001·Ultrasound in Medicine & Biology·N VykhodtsevaK Hynynen
Mar 28, 2003·Ultrasound in Medicine & Biology·R L KingK Hynynen
Nov 6, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Chenchen BingRajiv Chopra
Jun 20, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hao-Li LiuYung-Yaw Chen
Aug 14, 2012·Zeitschrift für medizinische Physik·Jürgen W JenneMatthias Günther
Sep 20, 2011·Cancer Treatment Reviews·Osama Al-BatainehPeter Huber
Jul 22, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brian J SchmidtMarcel R Böhmer
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·L R Gavrilov, J W Hand
Oct 26, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Mingzhu LuHui Zhong
Jan 26, 2000·IEEE Transactions on Bio-medical Engineering·T Fjield, K Hynynen
Oct 9, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marc A SantosKullervo Hynynen
Aug 12, 1999·Physics in Medicine and Biology·T FjieldK Hynynen
Apr 18, 2002·Journal of Applied Clinical Medical Physics·Tao Wu, Joel P Felmlee
Aug 6, 2016·Physics in Medicine and Biology·Kullervo Hynynen, Ryan M Jones
Jan 5, 2002·Physics in Medicine and Biology·R ChopraM J Bronskill
Dec 14, 2018·Physics in Medicine and Biology·Jason L RaymondRonald A Roy

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