Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults

BMC Nutrition
Lacey M BaldiviezCharles B Stephensen

Abstract

Metabolic imbalance is a key determinant of risk of chronic diseases. Metabolic health cannot be assessed solely by body mass calculations or by static, fasted state biochemical readouts. Although previous studies have described temporal responses to dietary challenges, these studies fail to assess the environmental factors associated with certain metabolic phenotypes and therefore, provide little scientific rationale for potentially effective intervention strategies. In this phenotyping study of healthy US adults, we are evaluating lifestyle, biological and environmental factors in addition to metabolic parameters to determine the factors associated with variations in metabolic health. A series of practical fitness, dietary, and emotional challenges are introduced and temporal responses in various areas of specialization, including immunology, metabolomics, and endocrinology, are monitored. We expect that this study will identify key factors related to healthy or unhealthy metabolic phenotypes (metabotypes) that may be modifiable targets for the prevention of chronic diseases in an individual. This study will provide novel insights into metabolic variability among healthy adults in balanced strata defined by sex, age and body ...Continue Reading

References

Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Oct 19, 2004·Atherosclerosis·A J H H M van OostromM Castro Cabezas
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jan 6, 2009·Appetite·Ashley N GearhardtKelly D Brownell
Mar 17, 2010·Journal of Physical Activity & Health·Ruth E Taylor-PiliaeStephen P Fortmann
Oct 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thi Ai DiepHarald Severin Hansen
Apr 14, 2012·International Journal of Vascular Medicine·M MoerlandJ Burggraaf
Feb 19, 2013·Journal of the Academy of Nutrition and Dietetics·Patricia M GuentherSusan M Krebs-Smith
Aug 1, 2013·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Mitsunori KayanoSatoru Miyano
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Sep 19, 2014·European Journal of Clinical Investigation·Pablo Perez-MartinezJose Lopez-Miranda
Jul 23, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alwine F M KardinaalSuzan Wopereis

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Methods Mentioned

BETA
saliva collection
blood draw
hysterectomy
X-ray
urine collection
flow cytometry
density gradient centrifugation
ELISA
Genotyping
PCR

Clinical Trials Mentioned

NCT02367287

Software Mentioned

MindWare
Excel
Inquisit 3 Lab
NutritionQuest
Research Electronic Data Capture ( [UNK] )
REDCap
Nutrient Data System for Research
MS
Quantitative Insights into Microbial Ecology
SDI Spirolab II

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