Abstract
The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830 nm. The system is based on a network analyzer, which provides rf modulation signals for the laser diodes, as well as measures the amplitude and the phase of the detected signals. Six different modulation frequencies ranging from 110 to 280 MHz are used. The details of instrumentation, calibration, data acquisition, and performance of the system are given. A finite element algorithm is used to solve the diffusion equation, and an inverse solver based on this forward solver is implemented to calculate the absorption and scattering maps from the acquired data. Data acquisition for one wavelength is completed in less than 2.5 min for a single modulation frequency. The measurement repeatability is 0.5% in ac intensity and 0.2 deg in phase. The performance of the system is evaluated with phantom studies. A multifrequency reconstruction algorithm is used, in which a single absorption and scattering image pair is obtained using the whole dataset obtained at different modulation frequencies. It is shown that the multifrequency reconstruction approach provides superior i...Continue Reading
References
May 1, 1995·Physics in Medicine and Biology·M FirbankD T Delpy
Jan 1, 1996·Medical Physics·S FantiniM Kaschke
May 1, 1997·Physics in Medicine and Biology·S R Arridge, J C Hebden
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·B J TrombergJ Butler
Jan 3, 2001·NeuroImage·D A BoasJ B Mandeville
Mar 16, 2001·Breast Cancer Research : BCR·V Ntziachristos, B Chance
Jan 31, 2002·Journal of Biomedical Optics·A E CerussiB J Tromberg
May 8, 2002·Applied Optics·Feng GaoYukio Yamada
Jan 10, 2003·Applied Optics·Hamid DehghaniKeith D Paulsen
Feb 28, 2003·Medical Physics·J P CulverA G Yodh
Apr 10, 2003·Journal of Biomedical Optics·Shudong JiangKeith D Paulsen
Jun 7, 2003·Applied Optics·Jonathan J StottDavid A Boas
Oct 18, 2003·Advances in Experimental Medicine and Biology·Troy O McBrideKeith D Paulsen
Feb 5, 2004·Optics Letters·Ang LiDavid A Boas
Mar 11, 2004·Applied Optics·Xiaomei SongKeith D Paulsen
Jun 12, 2004·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Adam B MilsteinKevin J Webb
Jul 27, 2004·Physics in Medicine and Biology·Xavier IntesBritton Chance
Dec 1, 2004·Journal of Biomedical Optics·Michael GurfinkelEva M Sevick-Muraca
Mar 6, 2008·Applied Optics·D GrosenickP M Schlag
Mar 8, 2008·Applied Optics·T O McBrideK D Paulsen
Mar 1, 1995·Optics Letters·M A O'LearyA G Yodh
Citations
Oct 28, 2011·Journal of Biomedical Optics·Yuting LinGultekin Gulsen
Dec 12, 2012·Journal of Biomedical Optics·Calvin B Shaw, Phaneendra K Yalavarthy
Dec 14, 2011·Sensors·Seung Nam SonChang-Seok Kim
Aug 4, 2011·International Journal of Biomedical Imaging·Michael GhijsenGultekin Gulsen
Feb 8, 2008·International Journal of Biomedical Imaging·Huacheng FengJunjie Yao
Mar 5, 2008·Journal of Biomedical Optics·Sachin V Patwardhan, Joseph P Culver
Nov 22, 2008·Journal of Biomedical Optics·Keun-Sik NoAlbert Cerussi
Jan 7, 2009·Journal of Biomedical Optics·Mehmet Burcin UnluGultekin Gulsen
Jan 12, 2010·Journal of Biomedical Optics·Xuejun GuAndreas H Hielscher
Apr 9, 2014·IEEE Transactions on Medical Imaging·Jaya PrakashPhaneendra K Yalavarthy
Jul 27, 2006·Technology in Cancer Research & Treatment·Gultekin GulsenOrhan Nalcioglu
Jul 27, 2006·Technology in Cancer Research & Treatment·Quing ZhuScott Kurtzman
Nov 10, 2006·Journal of Biomedical Optics·Mehmet Burcin UnluOrhan Nalcioglu
May 29, 2008·Physics in Medicine and Biology·Mehmet Burcin UnluGultekin Gulsen
Jun 4, 2019·Medical Physics·Ahmad AddoumFatmir Asllanaj
Jan 20, 2010·Technology in Cancer Research & Treatment·David ThayerGultekin Gulsen
Nov 29, 2017·Sensors·Hansol JangChang-Seok Kim
Sep 6, 2008·Optics Express·Weirong Mo, Nanguang Chen
Jan 25, 2011·Biomedical Optics Express·Vivek VenugopalXavier Intes
Jan 26, 2012·Optics Express·Nam-Seon SonMin-Cheol Oh
Apr 23, 2020·Frontiers in Neuroscience·Sergio Fantini, Angelo Sassaroli
Feb 16, 2013·Biomedical Optics Express·Wei ZhangFeng Gao