Design and implementation of a multifrequency near-infrared diffuse optical tomography system

Journal of Biomedical Optics
Gultekin GulsenOrhan Nalcioglu

Abstract

The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830 nm. The system is based on a network analyzer, which provides rf modulation signals for the laser diodes, as well as measures the amplitude and the phase of the detected signals. Six different modulation frequencies ranging from 110 to 280 MHz are used. The details of instrumentation, calibration, data acquisition, and performance of the system are given. A finite element algorithm is used to solve the diffusion equation, and an inverse solver based on this forward solver is implemented to calculate the absorption and scattering maps from the acquired data. Data acquisition for one wavelength is completed in less than 2.5 min for a single modulation frequency. The measurement repeatability is 0.5% in ac intensity and 0.2 deg in phase. The performance of the system is evaluated with phantom studies. A multifrequency reconstruction algorithm is used, in which a single absorption and scattering image pair is obtained using the whole dataset obtained at different modulation frequencies. It is shown that the multifrequency reconstruction approach provides superior i...Continue Reading

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Citations

Aug 4, 2011·International Journal of Biomedical Imaging·Michael GhijsenGultekin Gulsen
Feb 8, 2008·International Journal of Biomedical Imaging·Huacheng FengJunjie Yao
Mar 5, 2008·Journal of Biomedical Optics·Sachin V Patwardhan, Joseph P Culver
Nov 22, 2008·Journal of Biomedical Optics·Keun-Sik NoAlbert Cerussi
Jan 7, 2009·Journal of Biomedical Optics·Mehmet Burcin UnluGultekin Gulsen
Jan 12, 2010·Journal of Biomedical Optics·Xuejun GuAndreas H Hielscher
Apr 9, 2014·IEEE Transactions on Medical Imaging·Jaya PrakashPhaneendra K Yalavarthy
Jul 27, 2006·Technology in Cancer Research & Treatment·Gultekin GulsenOrhan Nalcioglu
Jul 27, 2006·Technology in Cancer Research & Treatment·Quing ZhuScott Kurtzman
Nov 10, 2006·Journal of Biomedical Optics·Mehmet Burcin UnluOrhan Nalcioglu
Jan 20, 2010·Technology in Cancer Research & Treatment·David ThayerGultekin Gulsen
Sep 6, 2008·Optics Express·Weirong Mo, Nanguang Chen
Jan 26, 2012·Optics Express·Nam-Seon SonMin-Cheol Oh
Apr 23, 2020·Frontiers in Neuroscience·Sergio Fantini, Angelo Sassaroli

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