Design and in vitro evaluation of tenofovir-loaded vaginal gels for the prevention of HIV infections

Pharmaceutical Development and Technology
Selin Seda TimurSema Çalış

Abstract

Infection with the human immunodeficiency virus (HIV) is affecting women disproportionally with increasing incidence rates over the last decades. Tenofovir is one of the most commonly used antiretroviral agents, which belongs to the nucleoside/nucleotide reverse transcriptase inhibitor family, for the prevention of HIV acquisition. In scope of this study, a thermogelling system containing tenofovir-loaded chitosan nanoparticles for the controlled release of tenofovir was developed and characterized. The in vitro release studies have shown that the burst release effect was decreased to 27% with f-TFV CS NPs-Gel. Gelation temperature of developed formulation was found as 26.6 ± 0.2 °C, which provides ease of administration while gelation occurs after the administration to the vagina. The work of adhesion values was used as parameters for comparison of mucoadhesive performance and the mucoadhesion of f-TFV CS NPs-Gel was found as 0.516 ± 0.136 N.s at 37 °C. The biocompatibility of blank formulations was evaluated by cell viability studies using L929 cells, in which Gel + CS NPs formulation was found to be safe with 82.4% and 90.2% cell viability for 1:16 and 1:32 dilutions, respectively. In conclusion, an improved tenofovir contai...Continue Reading

References

Jun 19, 2002·Antimicrobial Agents and Chemotherapy·J BalzariniA Holý
May 30, 2003·The Annals of Pharmacotherapy·Shellee A Grim, Frank Romanelli
Aug 4, 2004·International Journal of Pharmaceutics·Shirui MaoThomas Kissel
Jul 7, 2005·Tissue Engineering·Sarwat F KhattakSusan C Roberts
Sep 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haliza Katas, H Oya Alpar
Feb 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nartaya ThirawongPornsak Sriamornsak
Jun 11, 2008·Biomacromolecules·Ioannis A SogiasVitaliy V Khutoryanskiy
Jun 16, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Madaswamy S MuthuSanjay Singh
Dec 19, 2009·Expert Opinion on Drug Delivery·Rama Mallipeddi, Lisa Cencia Rohan
Jan 14, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Esra BalogluAndreas Bernkop-Schnürch
Mar 3, 2010·The AAPS Journal·Ahmed S ZidanMansoor A Khan
May 22, 2010·Indian Journal of Pharmaceutical Sciences·M MadanJ A Baig
Dec 2, 2010·The Journal of Antimicrobial Chemotherapy·Peter L AndersonRobert M Grant
Feb 22, 2011·International Journal of Pharmaceutics·Tofeeq Ur-RehmanGerhard Gröbner
Mar 26, 2011·Journal of Pharmaceutical Sciences·Dima AlukdaBi-Botti C Youan
Apr 5, 2011·International Journal of Pharmaceutics·Rathapon AsasutjaritSukitaya Veeranondha
Jun 28, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jianing MengBi-Botti C Youan
Sep 29, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sh AbashzadehF Atyabi
Feb 7, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jessica L Adams, Angela D M Kashuba
Apr 5, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·El-Sayed Ali IbrahimNoura Hassan Abdellah
Nov 8, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Laleh Erfani JabarianRassoul Dinarvand
Nov 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satiesh Kumar RamadassBalaraman Madhan
May 1, 2013·PloS One·Thanyanan ChaowanachanKim A Woodrow
Jul 28, 2013·International Journal of Pharmaceutics·Antonio RampinoAttilio Cesàro
Nov 1, 2013·Current Drug Delivery·Arshad Bashir Khan, Ram Sharnagat Thakur
Nov 14, 2013·BioMed Research International·H A MachadoK P Leung
Jan 23, 2014·Pharmaceutical Research·José das NevesBruno Sarmento
Sep 25, 2014·The Journal of Pathology·Sebastian Lucas, Ann Marie Nelson
Feb 17, 2015·Advanced Drug Delivery Reviews·Carla M CaramellaGiuseppina Sandri
Aug 6, 2015·The New England Journal of Medicine·Salim S Abdool KarimUNKNOWN CAPRISA 004 Trial Group
Aug 25, 2015·Journal of Biomaterials Science. Polymer Edition·Fatmanur Tuğcu-DemirözAykut Özkul

❮ Previous
Next ❯

Citations

Sep 19, 2017·Drug Delivery·Liling MeiChuanbin Wu
Sep 15, 2018·Pharmaceutics·Elena GiulianoDonato Cosco
Dec 19, 2020·International Journal of Biological Macromolecules·Sheersha Pramanik, Vaishnavi Sali
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Homa BoroumandHamed Mirzaei
Apr 26, 2021·International Journal of Pharmaceutics·Gabriela Corrêa CarvalhoMarlus Chorilli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.