PMID: 9651597Jul 4, 1998Paper

Design and in vitro results of a high intensity ultrasound interstitial applicator

Ultrasonics
C LafonD Cathignol

Abstract

Interstitial technologies were proposed for the treatment of deep-seated and unresectable tumours. This study was designed to demonstrate the possibility of producing coagulation necrosis for a short exposure duration (20s) and a large volume with an interstitial ultrasonic applicator equipped with a plane transducer. The applicator was evaluated in terms of electroacoustic efficiency (58% at 10.7 MHz), temperature pattern and in vitro pig liver tissues destruction. The temperature elevation reached 52, 39, 22 and 15 degrees C at, respectively, 2.5, 7.5 and 10 mm from the applicator surface along the propagation axis. The evident cigar-shaped lesions spread on a depth of (8 +/- 2) mm from the surface applicator, (10 +/- 1) mm high and (3 +/- 1) mm high and (3 +/- 1) mm wide. The temperature measurements showed the limitations encountered with a 10 MHz transducer. The high increase in temperature of tissues close to the transducer can induce vaporisation and a gaseous barrier opaque to ultrasound. Owing to the shape and the operating frequency of the transducer, we hope to obtain the same satisfactory performances in vivo with weakly perfusion-dependent lesions. Axial and longitudinal applicator motions will enable us to treat m...Continue Reading

References

Mar 1, 1994·The Journal of Urology·R L OchsE M Tan
Feb 1, 1997·IEEE Transactions on Bio-medical Engineering·K HynynenM Aguirre

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Citations

Feb 14, 2004·Ultrasound in Medicine & Biology·Cyril LafonDominique Cathignol
Aug 6, 2002·Ultrasonics·A StimacK Jambrosić
Mar 28, 2003·Ultrasound in Medicine & Biology·David MelodelimaDominique Cathignol
Apr 4, 2002·Medical Physics·Cyril LafonDominique Cathignol
Jan 29, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C J DiederichG Sommer

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