Abstract
Due to the excellent photoluminescent properties and singlet oxygen (1O2) generating efficiency, graphene quantum dots (GQDs) with maximal emission in near-infrared region (NIR) exhibited great potential in cancer imaging and therapy. However, GQDs can be cleared quickly via the renal system in vivo because of their ultrasmall size, which leads to the compromised cancer cell killing efficacy. Here, we report a hybrid nanoplatform, where GQDs were incorporated into the cavity of hollow mesoporous silica nanoparticles (hMSN) to form GQDs@hMSN-PEG nanoparticles (NPs). Optical characterization indicated that GQDs@hMSN-PEG NPs still maintained good absorption and emission properties from GQDs, and the composite NPs still possessed similar 1O2 generating efficiency. GQDs@hMSN-PEG NPs exhibited good biocompatibility in vitro and in vivo. High cargo-loading efficiency was achieved for doxorubicin (DOX), and the formed GQDs@hMSN(DOX)-PEG NPs showed the feasibility of tumor-oriented drug delivery. The extended retention time in tumor and good drug loading efficacy confirmed that GQDs@hMSN-PEG could serve as one promising candidate for combinational cancer treatment where photodynamic therapy and chemotherapy modules can be integrated int...Continue Reading
References
Oct 20, 2004·Nitric Oxide : Biology and Chemistry·Snezana M MirkovRadmila Z Kovacevic
Jun 16, 2005·Bioorganic & Medicinal Chemistry·Stanislav JaraczIwao Ojima
Nov 7, 2008·Biomaterials·Jun-Jie YinChunying Chen
Mar 11, 2010·Advanced Materials·Dengyu PanMinghong Wu
Jul 27, 2010·Biomaterials·Yang QiuChunying Chen
Sep 22, 2010·Journal of the American Chemical Society·Jian ZhangChad A Mirkin
Oct 23, 2010·Advanced Drug Delivery Reviews·Sarbari Acharya, Sanjeeb K Sahoo
Mar 29, 2012·Journal of the American Chemical Society·Minhuan LanPengfei Wang
Jul 17, 2012·Biomaterials·Zoran M MarkovicVladimir S Trajkovic
May 18, 2013·Advanced Materials·Yu ChenJianlin Shi
Jun 27, 2013·ACS Nano·Xin Ting ZhengPeng Chen
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
May 31, 2014·Scientific Reports·Feng ChenWeibo Cai
Jul 8, 2014·Nature Communications·Rong HeJ G Hou
Aug 12, 2014·Nature Communications·Jiechao GeXiaodong Han
Dec 28, 2009·Advanced Materials·Xiaohua HuangMostafa A El-Sayed
Apr 4, 2015·International Journal of Nanomedicine·Yang LiuHao Liu
May 9, 2015·Nanomedicine·Rubel ChakravartyWeibo Cai
Jul 8, 2015·ACS Nano·Mengxiao Yu, Jie Zheng
Oct 23, 2015·International Journal of Nanomedicine·Guomu LiuGuixiang Tai
Dec 24, 2015·Advanced Healthcare Materials·Jiechao GePengfei Wang
Mar 8, 2016·Journal of Biomedical Nanotechnology·Bei ChengPeisheng Xu
Mar 10, 2016·Scientific Reports·Xinyu WangYiyun Cheng
May 24, 2017·International Journal of Nanomedicine·Meng-Meng LuYan-Min Zhou
Jul 25, 2017·Nanomaterials·Anna Watermann, Juergen Brieger
Aug 31, 2017·ACS Central Science·Wenxing WangDongyuan Zhao
Citations
Jul 2, 2020·Advanced Drug Delivery Reviews·David C LutherVincent M Rotello
May 9, 2021·International Journal of Pharmaceutics·JinLing ZhengHongFei Chen
Jul 17, 2021·Journal of Nanobiotechnology·Guangman CuiGuangyu Yao
Feb 1, 2020·Current Medicinal Chemistry·Elzbieta Pedziwiatr-WerbickaMaria Bryszewska
Jan 16, 2022·Advanced Healthcare Materials·Yayun PengTing Cai