Design and operation of an automated high-throughput monoclonal antibody facility

Biophysics Reviews
Daniel LaytonEdouard C Nice

Abstract

Monoclonal antibodies now form a key part of the biochemist's toolbox, and are important reagents for therapeutic applications. This has resulted in a need for high-throughput production to satisfy the demand from the global community. Manual production involves overwhelming amounts of tissue culture and associated liquid handling steps to achieve high-throughput operation. By contrast, automated systems can readily cope with the numbers required. In this review, we address the development of automated systems, and discuss the pros and cons of their operation.

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Citations

Jan 25, 2017·Nature Communications·Mark S BakerShoba Ranganathan
Sep 27, 2018·Molecular Omics·Liyuan PengEdouard C Nice
Oct 18, 2016·Proteomics·Zhao HuangEdouard C Nice
May 28, 2014·Biomedical Chromatography : BMC·Kui WangEdouard Nice
Dec 31, 2014·Journal of Biomolecular Screening·Simon TickleDaniel Lightwood
Jun 16, 2015·Journal of Proteome Research·Péter HorvatovichWilliam S Hancock

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