Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm

Journal of Magnetic Resonance
Eriko S YoshimaruJulio Cárdenas-Rodríguez

Abstract

Pulsed Chemical Exchange Saturation Transfer (CEST) MRI experimental parameters and RF saturation pulse shapes were optimized using a multiobjective genetic algorithm. The optimization was carried out for RF saturation duty cycles of 50% and 90%, and results were compared to continuous wave saturation and Gaussian waveform. In both simulation and phantom experiments, continuous wave saturation performed the best, followed by parameters and shapes optimized by the genetic algorithm and then followed by Gaussian waveform. We have successfully demonstrated that the genetic algorithm is able to optimize pulse CEST parameters and that the results are translatable to clinical scanners.

References

Jan 1, 1997·Magnetic Resonance Imaging·B J FisherL D Hall
Oct 8, 1998·Journal of Magnetic Resonance·E LunatiF Osculati
Oct 22, 2003·Accounts of Chemical Research·Shanrong ZhangA Dean Sherry
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Silvio AimeEnzo Terreno
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Donald E WoessnerA Dean Sherry
Mar 24, 2007·Journal of Magnetic Resonance·Yong Pang, Gary X Shen
Jul 24, 2008·Annual Review of Biomedical Engineering·A Dean Sherry, Mark Woods
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael T McMahonPeter C M van Zijl
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe SunA Gregory Sorensen
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanshu LiuMark D Pagel
Sep 14, 2010·Magnetic Resonance Imaging·Kenya Murase, Nobuyoshi Tanki
Oct 16, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dario Livio LongoSilvio Aime
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin SchmittPeter Bachert
Mar 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhongliang ZuDaniel F Gochberg
Nov 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Craig K JonesPeter C M van Zijl
Jan 11, 2013·NMR in Biomedicine·Guanshu LiuMichael T McMahon
Jul 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiadi XuPeter C M van Zijl
Nov 28, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Liu Qi ChenMark D Pagel
Dec 18, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Kannie W Y ChanMichael T McMahon
Feb 27, 2014·Magma·Anja Müller-LutzHans-Jörg Wittsack
Apr 5, 2014·Contrast Media & Molecular Imaging·Edward A RandtkeMark D Pagel

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