Design and preclinical evaluation of nanostars for the passive pretargeting of tumor tissue.

Nuclear Medicine and Biology
Jeroen A C M GoosJason S Lewis

Abstract

Pretargeting strategies that do not rely on the expression of molecular targets have expanded imaging and therapy options for cancer patients. Nanostars with designed multivalency and which highly accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect may therefore be the ideal vectors for the development of a passive pretargeting approach. Nanostars were synthesized, consisting of 7-8 center-cross-linked arms that were modified with trans-cyclooctene (TCO) using poly(ethylene glycol) (PEG) linkers of 12 or 106 monomer units or without linker. The bioorthogonal click reaction with radiofluorinated 2,2'-(7-(2-(tetrazine-poly(ethyleneglycol)11-amino)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ([18F]F-Tz-PEG11-NODA) or 2,2'-(7-(2-(tetrazine-amino)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid ([18F]F-Tz-NODA) was measured by ex vivo biodistribution studies and positron emission tomography (PET) in mice bearing tumors with high EPR characteristics. Bioorthogonal masking was performed using a tetrazine-functionalized dextran polymer (Tz-DP). Highest tumor accumulation of [18F]F-Tz-PEG11-NODA was observed for nanostars functionalized with TCO without linker, with a tumor uptake of 3.2 ± 0.4...Continue Reading

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tommy CedervallSara Linse
Sep 2, 2009·Nuclear Medicine and Biology·Jason P HollandJason S Lewis
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
May 28, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Brian M ZeglisJason S Lewis
Oct 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Raffaella RossinMarc S Robillard
Jul 8, 2015·ACS Nano·Mengxiao Yu, Jie Zheng
Sep 8, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Song Yang KhorThomas P Davis
Oct 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jacob L HoughtonJason S Lewis
Jun 15, 2016·Chemical Reviews·Jing M RenGreg G Qiao
Oct 11, 2016·Chemical Society Reviews·Malay PatraGilles Gasser
Oct 28, 2016·Bioconjugate Chemistry·Jan-Philip MeyerBrian M Zeglis
Jun 27, 2017·ACS Omega·Outi KeinänenAnu J Airaksinen
Jul 1, 2017·Chemical Society Reviews·B L OliveiraG J L Bernardes
Jul 9, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohamed AltaiBrian M Zeglis
Sep 1, 2017·Journal of Medicinal Chemistry·Jan-Philip MeyerJason S Lewis
Sep 20, 2017·ACS Nano·Mattias BjörnmalmFrank Caruso
Oct 28, 2017·Nature Reviews. Materials·Hongmin ChenXiaoyuan Chen
Dec 6, 2017·ACS Nano·Pu Chun KeFrank Caruso
Jun 3, 2016·Bioengineering & Translational Medicine·Aaron C Anselmo, Samir Mitragotri
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·Clément BaillyJacques Barbet
Jun 7, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Patrícia M R PereiraJason S Lewis
Sep 5, 2019·Pharmaceutics·Marjolein VerhoevenSimone U Dalm
Oct 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Miaoyi WangPu Chun Ke

❮ Previous
Next ❯

Citations

Jan 29, 2021·EJNMMI Radiopharmacy and Chemistry·Mohammed Al-QahtaniDanielle Vugts
Jun 22, 2021·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Fangfang LvHuifang Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.