Design and protocol of a comprehensive multicentre biobank for abdominal aortic aneurysms

BMJ Open
Hamid JalalzadehRon Balm

Abstract

The pathophysiology and natural course of abdominal aortic aneurysms (AAAs) are insufficiently understood. In order to improve our understanding, it is imperative to carry out longitudinal research that combines biomarkers with clinical and imaging data measured over multiple time points. Therefore, a multicentre biobank, databank and imagebank has been established in the Netherlands: the 'Pearl Abdominal Aortic Aneurysm' (AAA bank). The AAA bank is a prospective multicentre observational biobank, databank and imagebank of patients with an AAA. It is embedded within the framework of the Parelsnoer Institute, which facilitates uniform biobanking in all university medical centres (UMCs) in the Netherlands. The AAA bank has been initiated by the two UMCs of Amsterdam UMC and by Leiden University Medical Center. Participants will be followed during AAA follow-up. Clinical data are collected every patient contact. Three types of biomaterials are collected at baseline and during follow-up: blood (including DNA and RNA), urine and AAA tissue if open surgical repair is performed. Imaging data that are obtained as part of clinical care are stored in the imagebank. All data and biomaterials are processed and stored in a standardised mann...Continue Reading

Associated Clinical Trials

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Citations

Aug 29, 2020·VASA. Zeitschrift für Gefässkrankheiten·Sigrid NikolChristine Espinola-Klein
Oct 27, 2021·European Journal of Clinical Investigation·Karlijn B RomboutsKak Khee Yeung

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Clinical Trials Mentioned

NCT03320408

Software Mentioned

Parelsnoer Repository for Information Specification
Project Manager Internet Server
PRISMA
Clinical Trial Processor

Related Concepts

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Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

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