PMID: 8595705Dec 1, 1995Paper

Design and representation of multivariate patient-based reference regions for arterial pH, PCO2 and base excess values

Clinical Biochemistry
M HekkingE S Gelsema

Abstract

To determine and compare the shape and location of three data sets of arterial pH, PCO2, and BE values from intensive care patients in a new acid-base chart for the purpose of deriving multivariate reference regions. The new chart is constructed by applying a statistical technique called principal component analysis (PCA). Three different data sets, each comprised of 1500 arterial pH, PCO2, and BE values, were subjected to PCA. The 3 data sets were collected in a respiratory intensive care unit (ICU) of a University Hospital, in a general ICU of a District Hospital, and in a neonatal ICU of a Children's Hospital. The outlines of the resulting charts are similar for all 3 data sets, but the representations of the three distributions in the new chart are highly dissimilar, both in shape and in location. PCA can be used to derive a patient-based reference region for arterial pH, PCO2, and BE values. Furthermore, the new chart may be useful for the graphical monitoring of acid-base data because distances between consecutive observations are faithfully represented.

References

Jul 1, 1991·Journal of Clinical Monitoring·J W Severinghaus
Apr 1, 1990·International Journal of Bio-medical Computing·H PincéJ L Willems
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·A Ait-BoulahsenF W Edens
Dec 1, 1969·Computers and Biomedical Research, an International Journal·M L Cohen
May 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·O Siggaard-Andersen
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSEN, K ENGEL
Sep 1, 1965·Anesthesiology·J P BUNKER

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Citations

Nov 6, 1998·Intensive Care Medicine·M HekkingE S Gelsema
Aug 26, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·James C Boyd
Jun 23, 2010·Pharmaceutical Statistics·Kimberly S CriminRobb J Muirhead

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